Category Archives: Population(s)
Current ARTs, virologic failure, and implications for AIDS management: A systematic review
Antiretroviral therapies (ARTs) have revolutionized the management of human immunodeficiency virus (HIV) infection, significantly improved patient outcomes, and reduced the mortality rate and incidence of acquired immunodeficiency syndrome (AIDS). However,...
The experience of healthcare workers to HIV pre-exposure prophylaxis (PrEP) implementation in low- and middle-income countries: A systematic review and qualitative meta-synthesis
BACKGROUND: The effectiveness of pre-exposure prophylaxis has been extensively documented. However, there are substantial gaps between the actual implementation of pre-exposure prophylaxis and the ideal goal, especially in low-and middle-income...
Immune reconstitution inflammatory syndrome, a controversial burden in the East African context: A systematic review and meta-analysis
Introduction It is well established that starting antiretroviral therapy (ART) increases a patient’s life expectancy among HIV-positive individuals. Considering the HIV pandemic, the major concern is initiation of ARTs to...
Human papillomavirus prevalence in pregnant women living with human immunodeficiency virus infection: A scoping review of the literature
Objectives Studies already pointed out the increased risk of human papillomavirus (HPV) positivity and the implied risk of cervical dysplasia and even cervical carcinoma in pregnant women with human immunodeficiency virus...
Disentangling opioids-related overdose syndemics: A scoping review
This article reviews research investigating the synergistic interaction of opioid-related morbidity and mortality with other social, psychiatric, and biological conditions, to describe how and why it is syndemic. Opioid-related overdose...
The association between HIV infection and precancerous cervical lesion. A systematic review and meta-analysis of case-control studies
BACKGROUND: The effect of human immunodeficiency virus (HIV) on precancerous cervical lesion is not consistent across studies. Besides to the variability in the presence of a significant association between HIV...
Global prevalence of chronic pain in women with HIV: A systematic review and meta-analysis
Chronic pain is common among people with human immunodeficiency virus (HIV) and detrimental to quality of life and overall health. It is often underdiagnosed, undertreated, and frankly dismissed in women...
HIV testing disruptions and service adaptations during the COVID-19 pandemic: A systematic literature review
Access to treatment and care in safe clinical settings improves people’s lives with HIV. The COVID-19 pandemic disrupted vital HIV programs and services, increasing the risk of adverse health outcomes...
Pharmacokinetics of antiretroviral drugs in older people living with HIV: A systematic review
Background and objective: The life expectancy of people living with HIV (PLWHIV) has significantly improved in recent decades, mostly due to antiretroviral (ARV) therapy. Aging can affect the pharmacokinetics of drugs...
Global associations of key populations with HIV-1 recombinants: A systematic review, global survey, and individual participant data meta-analysis
INTRODUCTION: Global HIV infections due to HIV-1 recombinants are increasing and impede prevention and treatment efforts. Key populations suffer most new HIV infections, but their role in the spread of...
Geographic and population distributions of HIV-1 and HIV-2 circulating subtypes: A systematic literature review and meta-analysis (2010–2021)
BACKGROUND: HIV continues to be a major source of morbidity and mortality. Among the main challenges faced by prophylactic HIV vaccine development are the high rates of genetic mutation and...
