Category Archives: Children or Youth (less than 18 years old)

Effectiveness of oral pre-exposure prophylaxis (PrEP) for HIV

2018

Key take-home messages Oral PrEP (tenofovir disoproxil fumarate with emtricitabine) is highly protective against HIV acquisition across various populations and across different dosing schedules. Open label and demonstration projects in...

Interventions for developmental delays in children born to HIV-infected mothers: A systematic review

2018

Children born to HIV-infected mothers have worse developmental outcomes compared to HIV-unexposed children. However, little is known about interventions to improve developmental outcomes in this population. This study systematically reviews...

Congenital HIV: Prevention of maternal to child transmission

2018

BACKGROUND: Human immunodeficiency virus (HIV) is caused by a cytopathic lentivirus. HIV without adequate treatment during pregnancy can result in maternal to child transmission (MCT) of the virus. Sequelae can...

Morbidity benefit conferred by childhood immunisation in relation to maternal HIV status: A meta-analysis of demographic and health surveys

2018

The study determined the prevalence of acute respiratory infections and diarrhoea among sub-Saharan African children. It also examined if there was any significant morbidity benefit conferred by three doses of...

HIV serostatus disclosure in the Democratic Republic of the Congo: A systematic review

2018

HIV status disclosure among people living with HIV/AIDS has been shown to have a number of both personal and public health benefits, but rates of HIV status disclosure remain low...

AIDS-affected orphans in Sub-Saharan Africa: A scoping review on outcome differences in rural and urban environments

2018

Currently, there are more than 11 million AIDS-affected orphans that suffer from various adverse effects, most of whom reside in sub-Saharan Africa. The difference between whether a child resides in...

Intergenerational interventions for people living with HIV and their families: A systematic review

2018

A variety of interventions have been tested targeting people living with HIV (PLH) and their relationships with their children. The purpose of this study was to synthesize evidence on the...

An overview of the case fatality of inpatient severe acute malnutrition in Ethiopia and its association with human immunodeficiency virus/tuberculosis comorbidity — A systematic review and meta-analysis

2018

Background: Mortality of children with severe acute malnutrition (SAM) is a devastating problem in Ethiopia. This study estimated the pooled case fatality ratio of SAM among children <5 y of...

eHealth to enhance treatment adherence among youth living with HIV

2018

PURPOSE OF REVIEW: Multiple reviews have examined eHealth/mHealth interventions to address treatment adherence, including those focusing on youth living with HIV (YLWH). This review synthesizes results of prior reviews and...

Antiretroviral therapy interruptions: Impact on HIV treatment and transmission

2018

Introduction: Successful management of pediatric and adult human immunodeficiency virus (HIV) disease includes lifelong administration of antiretroviral therapy (ART). The need for the continuous use of antiretroviral drugs throughout the...

A systematic review and meta-analysis of vertical transmission route of HIV in Ethiopia

2018

BACKGROUND: The burden of mother-to-child transmission rate of HIV is high and risk factors are common in Ethiopia. This systematic review and meta-analysis intended to provide the pooled estimation of...

Comparative safety and effectiveness of perinatal antiretroviral therapies for HIV-infected women and their children: Systematic review and network meta-analysis including different study designs

2018

BACKGROUND: Nearly all newly infected children acquire Human Immunodeficiency virus (HIV) via mother-to-child transmission (MTCT) during pregnancy, labour or breastfeeding from untreated HIV-positive mothers. Antiretroviral therapy (ART) is the standard...

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