Category Archives: Children or Youth (less than 18 years old)
Which HIV-infected youth are at risk of developing depression and what treatments help? A systematic review focusing on Southern Africa
Background Depression is common in people with HIV and is associated with lower quality of life, reduced medication adherence, worse disease progression and higher risk of transmission to others. While...
Effectiveness of pneumococcal conjugate vaccination against invasive pneumococcal disease among children with and those without HIV infection: A systematic review and meta-analysis
BACKGROUND: HIV-infected children are at a higher risk of Invasive Pneumococcal Disease (IPD) and its mortality, even in the era of antiretroviral therapy. Therefore, an effective vaccination strategy would be...
Barriers and facilitators to the successful transition of adolescents living with HIV from pediatric to adult care in low and middle-income countries: A systematic review and policy analysis
The purpose of this systematic review was twofold. First, we sought to summarize the literature on barriers and facilitators to successful healthcare transition for adolescents living with HIV from low-...
Use of an indeterminate range in HIV early infant diagnosis: A systematic review and meta-analysis
BACKGROUND: Expanded access to HIV antiretrovirals has dramatically reduced mother-to-child transmission of HIV. However, there is increasing concern around false-positive HIV test results in perinatally HIV-exposed infants but few insights...
Interventions to reduce gender-based violence among young people living with or affected by HIV/AIDS in low-income and middle-income countries
OBJECTIVE(S): This study explored the effectiveness of gender-based violence (GBV) interventions on young people living with or affected by HIV in low- and middle-income countries (LMICs). DESIGN: Systematic review and...
Causal effects of education on sexual and reproductive health in low and middle-income countries: A systematic review and meta-analysis
Background: Despite strong theoretical grounding, important gaps in knowledge remain regarding the degree to which there is a causal relationship between education and sexual and reproductive health, as many claims have...
Immunogenicity and safety of measles vaccine in HIV-infected children: An updated systematic review
Human immunodeficiency virus (HIV)-infected children are at increased risk of measles morbidity and mortality. We searched abstracts from the PubMed, Embase, and Latin American and Caribbean Health Sciences databases for...
Safety and immunogenicity of measles vaccination in HIV-infected and HIV-exposed uninfected children: A systematic review and meta-analysis
Background: HIV-infected and HIV-exposed uninfected (HEU) children have an increased risk of measles that may be due to altered immune responses or suboptimal timing of measles vaccination. We aimed to...
Risk factors for indeterminate interferon-gamma release assay for the diagnosis of tuberculosis in children-A systematic review and meta-analysis
Background: Interferon-gamma release assays (IGRA) are well-established immunodiagnostic tests for tuberculosis (TB) in adults. In children these tests are associated with higher rates of false-negative and indeterminate results. Age is...
Recent interventions to improve retention in HIV care and adherence to antiretroviral treatment among adolescents and youth: A systematic review
Adolescents represent a growing proportion of people living with HIV worldwide and the highest risk population group for treatment attrition and AIDS-related mortality. There is an urgent need to design,...
