Category Archives: Treatment
A review of the efficacy and safety of genvoya(R) (elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide) in the management of HIV-1 infection
INTRODUCTION: This review evaluates the efficacy and safety of Genvoya(R) (elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide [EVG/c/TAF/FTC]), a single-tablet regimen used for the management of HIV-1 infection. Phase II and...
Critical review: What dose of rifabutin is recommended with antiretroviral therapy?
Since the advent of combination antiretroviral therapy to successfully treat HIV infection, drug-drug interactions (DDIs) have become a significant problem as many antiretrovirals (ARVs) are metabolized in the liver. Antituberculous...
HIV-associated executive dysfunction in the era of modern antiretroviral therapy: A systematic review and meta-analysis
OBJECTIVE: While some reports suggest that HIV+ individuals continue to display executive function (EF) impairment in the era of cART, findings have been contradictory and appear to differ based on...
Non-communicable diseases and HIV care and treatment: Models of integrated service delivery
OBJECTIVES: Non-communicable diseases (NCD) are a growing cause of morbidity in low-income countries including in people living with human immunodeficiency virus (HIV). Integration of NCD and HIV services can build...
Assessing the feasibility of eHealth and mHealth: A systematic review and analysis of initiatives implemented in Kenya
BACKGROUND: The growth of Information and Communication Technology in Kenya has facilitated implementation of a large number of eHealth projects in a bid to cost-effectively address health and health system...
Comprehensive review of the evidence regarding the effectiveness of community-based primary health care in improving maternal, neonatal and child health: 1. rationale, methods and database description
BACKGROUND: Community-based primary health care (CBPHC) is an approach used by health programs to extend preventive and curative health services beyond health facilities into communities and even down to households....
Impact of highly active antiretroviral therapy on the prevalence of oral lesions in HIV-positive patients: A systematic review and meta-analysis
The aim of this study was to determine whether highly active antiretroviral therapy (HAART) is associated with the prevalence of oral lesions in HIV-positive patients. This systematic review and meta-analysis...
Adverse effects of oral second-line antituberculosis drugs in children
INTRODUCTION: Increasing numbers of children with drug-resistant tuberculosis are accessing second-line antituberculosis drugs; these are more toxic than first-line drugs. Little is known about the safety of new antituberculosis drugs...
Postnatal HIV transmission in breastfed infants of HIV-infected women on ART: A systematic review and meta-analysis
INTRODUCTION: To systematically review the literature on mother-to-child transmission in breastfed infants whose mothers received antiretroviral therapy and support the process of updating the World Health Organization infant feeding guidelines...
