Category Archives: Treatment
The association between HIV (treatment), pregnancy serum lipid concentrations and pregnancy outcomes: A systematic review
BACKGROUND: Observed adverse effects of antiretroviral therapy (ART) on the lipid profile could be of significance in pregnancy. This systematic review aims to summarize studies that investigated the association between...
Reliability of white matter microstructural changes in HIV infection: Meta-analysis and confirmation
BACKGROUND: Diffusion tensor imaging has been widely used to measure HIV effects on white matter microarchitecture. While many authors have reported reduced fractional anisotropy and increased mean diffusivity in HIV,...
Examining the health and health service utilization of heterosexual men with HIV: A community-informed scoping review
The prevalence of HIV infection among heterosexual men has increased. Consequently, the need for health and support services for this group is likely to increase. We conducted a scoping review...
Determinants of adherence to antiretroviral therapy among HIV-positive adults in sub-Saharan Africa: A systematic review
OBJECTIVE: The rapid scale up of antiretroviral treatment (ART) in sub-Saharan Africa (SSA) has resulted in an increased focus on patient adherence. Non-adherence can lead to drug-resistant HIV caused by...
Clinical and public health implications of acute and early HIV detection and treatment: A scoping review
INTRODUCTION: The unchanged global HIV incidence may be related to ignoring acute HIV infection (AHI). This scoping review examines diagnostic, clinical, and public health implications of identifying and treating persons...
Systematic review and meta-analysis of the adolescent HIV continuum of care in South Africa: the Cresting Wave
CONTEXT: South Africa has the most HIV infections of any country in the world, yet little is known about the adolescent continuum of care from HIV diagnosis through viral suppression....
HIV-free survival at 12-24 months in breastfed infants of HIV-infected women on antiretroviral treatment
OBJECTIVE: To provide estimates of HIV-free survival at 12-24 months in breastfed children by maternal ART (6 months or lifelong) to inform WHO HIV and Infant Feeding guidelines. METHODS: Eighteen...
The electrophysiology of neuroHIV: A systematic review of EEG and MEG studies in people with HIV infection since the advent of highly-active antiretroviral therapy
OBJECTIVE: The Human Immunodeficiency Virus (HIV) has an impact on the brain, even when the infection is well-controlled with modern highly-active antiretroviral therapy (HAART). While dementia is rare in those...
Integrated opioid substitution therapy and HIV care: A qualitative systematic review and synthesis of client and provider experiences
People who use drugs in many contexts have limited access to opioid substitution therapy and HIV care. Service integration is one strategy identified to support increased access. We reviewed and...
HCV cure and reinfection among people with HIV/HCV coinfection and people who inject drugs
PURPOSE OF REVIEW: Highly effective, well-tolerated interferon-free direct-acting antivirals (DAA) have revolutionised hepatitis C virus (HCV) therapeutics, with the opportunity for broad treatment scale-up among marginalised or “high-risk” populations, including...
