Category Archives: Treatment
Is there scope for cost savings and efficiency gains in HIV services? A systematic review of the evidence from low- and middle-income countries
OBJECTIVE: To synthesize the data available–on costs, efficiency and economies of scale and scope–for the six basic programmes of the UNAIDS Strategic Investment Framework, to inform those planning the scale-up...
Discontinuation of tenofovir disoproxil fumarate for presumed renal adverse events in treatment-naïve HIV-1 patients: Meta-analysis of randomized clinical studies
Background: Safety and efficacy of tenofovir disoproxil fumarate (TDF) as a component of antiretroviral therapy (ART) have been demonstrated in clinical trials. TDF nephrotoxicity has been reported in both HIV-infected...
Global burden of transmitted HIV drug resistance and HIV-exposure categories: A systematic review and meta-analysis
OBJECTIVES: Our aim was to review the global disparities of transmitted HIV drug resistance (TDR) in antiretroviral-naive MSM, people who inject drugs (PWID) and heterosexual populations in both high-income and...
Systematic literature review and meta-analysis of renal function in human immunodeficiency virus (HIV)-infected patients treated with Atazanavir (ATV)-based regimens
Some HIV antiretroviral therapies (ART) have been associated with renal toxicities, which become of increasing concern as HIV-infected patients age and develop comorbidities. The objective of this study was to...
Review: An urgent need for research on factors impacting adherence to and retention in care among HIV-positive youth and adolescents from key populations
INTRODUCTION: The 50% increase in HIV-related deaths in youth and adolescents (aged 10-24) from 2005 to 2012 highlights the need to improve HIV treatment and care in this population, including...
The effect of early initiation of antiretroviral therapy in TB/HIV coinfected patients: A systematic review and meta-analysis
BACKGROUND: The importance of early initiation of antiretroviral therapy (ART) for tuberculosis (TB) and HIV coinfected patients is controversial. We conducted a systematic review and meta-analysis to assess the effect...
Contemporary issues on the epidemiology and antiretroviral adherence of HIV-infected adolescents in sub-Saharan Africa: A narrative review
INTRODUCTION: Adolescents are a unique and sometimes neglected group in the planning of healthcare services. This is the case in many parts of sub-Saharan Africa, where more than eight out...
The HIV care cascade: A systematic review of data sources, methodology and comparability
INTRODUCTION: The cascade of HIV diagnosis, care and treatment (HIV care cascade) is increasingly used to direct and evaluate interventions to increase population antiretroviral therapy (ART) coverage, a key component...
Nevirapine versus efavirenz for patients co-infected with HIV and tuberculosis: A systematic review and meta-analysis
OBJECTIVES: Antiretroviral therapy (ART) reduces the morbidity and mortality of patients infected with HIV. Standard ART includes either nevirapine or efavirenz, however the efficacy of these drugs is limited in...
Incidence of HIV-associated tuberculosis among individuals taking combination antiretroviral therapy: A systematic review and meta-analysis.
BACKGROUND: Knowledge of tuberculosis incidence and associated factors is required for the development and evaluation of strategies to reduce the burden of HIV-associated tuberculosis. METHODS: Systematic literature review and meta-analysis...
Adherence to HIV postexposure prophylaxis: A systematic review and meta-analysis
INTRODUCTION: We evaluated variations in completion rates for HIV postexposure prophylaxis (PEP) according to the exposure type (occupational, nonoccupational, and sexual assault), patient, and programme characteristics. METHODS: Four major databases...
