Category Archives: Treatment
Efficacy of protease inhibitor monotherapy vs. triple therapy: Meta-analysis of data from 2303 patients in 13 randomized trials
OBJECTIVES: The aim of this analysis was to review the evidence and update a meta-analysis evaluating the efficacy and safety results from randomized controlled trials of ritonavir-boosted protease inhibitor (PI/r)...
The cost and impact of scaling up pre-exposure prophylaxis for HIV prevention: A systematic review of cost-effectiveness modelling studies
BACKGROUND: Cost-effectiveness studies inform resource allocation, strategy, and policy development. However, due to their complexity, dependence on assumptions made, and inherent uncertainty, synthesising, and generalising the results can be difficult....
The prevalence of HIV-1 drug resistance among antiretroviral treatment naïve individuals in mainland China: A meta-analysis
BACKGROUND: Surveillance of drug resistance in antiretroviral treatment-naive patients in China is needed to ensure optimal treatment outcomes and control of the human immunodeficiency virus (HIV) epidemic. METHODS: A systematic...
Metabolic complications of in utero maternal HIV and antiretroviral exposure in HIV-exposed infants
BACKGROUND: Despite a wide body of literature supporting the use of antenatal antiretrovirals (ARV) for the prevention of mother-to-child transmission, there remains a need for continued monitoring as the intrauterine...
Service delivery interventions to improve adolescents’ linkage, retention and adherence to antiretroviral therapy and HIV care
OBJECTIVES: Adolescents living with HIV face substantial difficulties in accessing HIV care services and have worse treatment outcomes than other age groups. The objective of this review was to evaluate...
Comparative effectiveness of tenofovir in treatment-naive HIV-infected patients: Systematic review and meta-analysis
INTRODUCTION: Benefits and harms of tenofovir disoproxil fumarate (TDF) in HIV-infected, antiretroviral treatment (ART)-naive patients of any age have not been systematically reviewed since recent milestone trials were published. METHODS:...
Long-term virological outcomes of first-line antiretroviral therapy for HIV-1 in low- and middle-income countries: A systematic review and meta-analysis
BACKGROUND: More than 11.7 million people are currently receiving antiretroviral therapy (ART) in low- and middle-income countries (LMICs), and focused efforts are needed to ensure high levels of adherence and...
Social media and HIV: A systematic review of uses of social media in HIV communication
BACKGROUND: Social media, including mobile technologies and social networking sites, are being used increasingly as part of human immunodeficiency virus (HIV) prevention and treatment efforts. As an important avenue for...
Interventions to promote adherence to antiretroviral therapy in Africa: A network meta-analysis
BACKGROUND: Adherence to antiretroviral therapy (ART) is necessary for the improvement of the health of patients and for public health. We sought to determine the comparative effectiveness of different interventions...
The effect of tuberculosis treatment on virologic and CD4+ cell count response to combination antiretroviral therapy: A systematic review
OBJECTIVES: To determine the impact of tuberculosis (TB) treatment at the time of combination antiretroviral therapy (cART) initiation on virologic and CD4 cell count response to cART. METHODS:: Systematic review...
Adherence to antiretroviral therapy in adolescents living with HIV: Systematic review and meta-analysis
OBJECTIVE: Adolescent and young adult (AYA) populations (12-24 years) represent over 40% of new HIV infections globally. Adolescence is sometimes characterized by high-risk sexual behaviour and a lack of engagement...
