Category Archives: Treatment

Effect of directly observed therapy for highly active antiretroviral therapy on virologic, immunologic, and adherence outcomes: A meta-analysis and systematic review

2010

Introduction: Directly observed therapy of highly active antiretroviral therapy (DOT-HAART) is a feasible adherence intervention. Prospective DOT-HAART studies have shown mixed results, and optimal target groups have yet to be...

Iron supplementation for reducing morbidity and mortality in children with HIV

2009

BACKGROUND: The most prevalent haematologic disturbance associated with HIV in children (apart from CD4 lymphocytopenia) is anaemia. Anaemia associated with HIV arises from multiple mechanisms, including the direct inhibitory effect...

HIV type-1 drug resistance in treatment-naive patients monitored using minority species assays: A systematic review and meta-analysis

2011

BACKGROUND: The detection of mutations associated with drug resistance in HIV type-1 might be increased by applying minority species assays capable of identifying low frequency mutations in comparison with the...

Nevirapine once daily: Pharmacology, metabolic profile and efficacy data of the new extended-release formulation

2011

Introduction: Nevirapine (NVP), a non-nucleoside reverse transcriptase inhibitor, has been an important component of HIV infection treatment for many years. Currently, twice-a-day dosing is required for the successful application of...

Randomised controlled trials in Africa of HIV and AIDS: Descriptive study and spatial distribution

2005

OBJECTIVES: To identify and describe randomised controlled trials on HIV and AIDS conducted in Africa and to map their spatial distribution using exact geographic coordinates. DESIGN: Construction and analysis of...

Informal caregivers of persons with HIV/AIDS: A review and analysis

2003

Due to advanced antiretroviral treatments, persons with HIV/AIDS (PWH/As) live longer and experience various physical and cognitive impairments during the course of their disease. Often, informal caregivers assist PWH/As to...

Assessing the impact of HAART on the incidence of defining and non-defining AIDS cancers among patients with HIV/AIDS: A systematic review

2015

After highly active antiretroviral therapy (HAART) became widespread, several studies demonstrated changes in the incidence of defining and non-defining AIDS cancers among HIV/AIDS patients. We conducted a systematic review of...

Role of the inhibitory quotient in HIV therapy

2005

A systemic review is presented of all studies that have evaluated the inhibitory quotient (IQ). The IQ is defined as the ratio between (trough) drug concentration and level of drug...

Circulating endothelial progenitor cells in HIV infection: A systematic review

2013

Human immunodeficiency virus (HIV)-infected individuals have a cardiovascular disease risk that is almost thrice than that of their HIV-uninfected counterparts. Given the critical role of endothelial progenitor cells (EPCs) in...

Effects of vitamin D deficiency and combination antiretroviral therapy on bone in HIV-positive patients

2012

Objectives: In the era of combination antiretroviral therapy (cART), vitamin D deficiency, low bone mineral density (BMD) and fractures have emerged as subjects of concern in HIV-positive patients. Testing for...

Is there a role for primary care clinicians in providing shared care in HIV treatment? A systematic literature review

2012

BACKGROUND: Despite HIV being increasingly considered as a chronic illness, there is as yet no consensus about how primary care should be integrated with specialty care to provide optimal clinical...

Treatment of severe or progressive Kaposi’s sarcoma in HIV-infected adults

2014

Background: Kaposi’s sarcoma remains the most common cancer in Sub-Saharan Africa and the second most common cancer in HIV-infected patients worldwide. Since the introduction of highly active antiretroviral therapy (HAART),...

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