Category Archives: Treatment
Rates of emergence of HIV drug resistance in resource-limited settings: A systematic review
BACKGROUND: The increasing availability of antiretroviral therapy (ART) has improved survival and quality of life for many infected with HIV, but can also engender drug resistance. This review summarizes the...
The effectiveness of HIV partner counseling and referral services in increasing identification of HIV-positive individuals: A systematic review
Partner counseling and referral services (PCRS) are part of the spectrum of care for HIV-positive people and their sexual or needle-sharing partners. Referral includes notifying partners of exposure, after which...
Effectiveness of protease inhibitor monotherapy versus combination antiretroviral maintenance therapy: A meta-analysis
BACKGROUND: The unparalleled success of combination antiretroviral therapy (cART) is based on the combination of three drugs from two classes. There is insufficient evidence whether simplification to ritonavir boosted protease...
A narrative review of research on the effects of physical activity on people living with HIV and opportunities for health promotion in disadvantaged settings
The article explores different types and effects of physical activity for people living with HIV. Considering the lack of studies done in African contexts and the disparity between research settings...
Efficacy of selected treatments of HIV wasting: A systematic review and meta-analysis
PURPOSE: To assess the efficacy of recombinant human growth hormone (rhGH), testosterone, and anabolic steroids in the treatment of HIV wasting. METHODS: A systematic review and meta-analysis of studies published...
Diarrhea associated with lopinavir/ritonavir-based therapy: Results of a meta-analysis of 1469 HIV-1-infected participants
BACKGROUND: Antiretroviral therapy is associated with adverse events (AEs). The most frequently reported AE associated with lopinavir/ritonavir (LPV/r) containing regimens is diarrhea. The objective of this meta-analysis is to describe...
Redressing the epidemics of opioid overdose and HIV among people who inject drugs in Central Asia: The need for a syndemic approach
BACKGROUND: Accumulating evidence suggests that opioid overdose and HIV infection are burgeoning intertwined epidemics among people who inject drugs (PWID) in Central Asia. To date, however, research on overdose and...
Stable bone density in HAART-treated individuals with HIV: A meta-analysis
Context: Longitudinal studies of bone mineral density (BMD) in HIV have reported conflicting results. Objective: We investigated whether temporal changes in BMD differ by highly active antiretroviral therapy (HAART) status...
The other genome: A systematic review of studies of mitochondrial DNA haplogroups and outcomes of HIV infection and antiretroviral therapy
Mitochondrial toxicity is implicated in some treatment-limiting antiretroviral therapy complications, and reports of mitochondrial dysfunction in untreated HIV infection suggest antiretroviral therapy independent effects of HIV. Several studies have explored...
Child-rearing practices of primary caregivers of HIV-infected children: An integrative review of the literature
The number of human immunodeficiency virus (HIV)-infected children has increased because of the HIV and acquired immunodeficiency syndrome epidemic. Yet little is known about the child-rearing practices of these children’s...
