Category Archives: Treatment
Treatment-related optimistic beliefs and risk of HIV transmission: A review of recent findings (2009-2012) in an era of treatment as prevention
The promising outlook for HIV treatment as prevention (TasP) offered by the recent success in clinical trials has highlighted the need for effort against over-optimism toward anti-retroviral therapy (ART). It...
A meta-analysis of six placebo-controlled trials of thiazolidinedione therapy for HIV lipoatrophy
Objective: To determine the impact of thiazolidinediones (TZD) on changes in limb fat mass in HIV-infected individuals, particularly in those not receiving a thymidine analogue.Methods: Individual patient data from placebo-controlled,...
A review of anti-D treatment of childhood idiopathic thrombocytopenic purpura
Treatment of childhood idiopathic thrombocytopenic purpura is still an area of controversy. We reviewed the literature on anti-D treatment. Most studies used intravenous anti-D. Single doses of 50 microg/kg increased...
Yield of HIV-associated tuberculosis during intensified case finding in resource-limited settings: A systematic review and meta-analysis
Intensified case finding is the regular screening for evidence of tuberculosis in people infected with HIV, at high risk of HIV, or living in congregate settings. We systematically reviewed studies...
Evidence behind the WHO guidelines: Hospital Care for Children: What is the aetiology and treatment of chronic diarrhoea in children with HIV?
The World Health Organization has produced guidelines for the management of common illnesses in hospitals with limited resources. This series reviews the scientific evidence behind WHO’s recommendations. The WHO guidelines,...
Integration of HIV/AIDS services with maternal, neonatal and child health, nutrition, and family planning services
Background: The integration of HIV/AIDS and maternal, neonatal, child health and nutrition services (MNCHN), including family planning (FP) is recognized as a key strategy to reduce maternal and child mortality...
HIV monotherapy with ritonavir-boosted protease inhibitors: A systematic review
Objective: To assess the efficacy of ritonavir-boosted protease inhibitor monotherapy. Design and methods: Systematic review of all protease inhibitor-monotherapy studies published in peer-reviewed journals or presented at conferences to date....
Meta-analysis of the safety, tolerability, and efficacy of lopinavir/ritonavir-containing antiretroviral therapy in HIV-1-infected women
PURPOSE: Women comprise ≯50% of HIV-infected patients, yet safety, tolerability, and efficacy data in women taking antiretrovirals (ARVs) are limited. Lopinavir/ ritonavir (LPV/r)-anchored regimens are globally the most widely prescribed...
Gender distribution of adult patients on highly active antiretroviral therapy (HAART) in Southern Africa: A systematic review
BACKGROUND: HIV and AIDS are significant and growing public health concerns in southern Africa. The majority of countries in the region have national adult HIV prevalence estimates exceeding 10 percent....
Systematic review of the safety of trimethoprim-sulfamethoxazole for prophylaxis in HIV-infected pregnant women: Implications for resource-limited settings
Daily prophylaxis with trimethoprim-sulfamethoxazole (TMP-SMZ) significantly decreases morbidity and mortality among people living with HIV. Some clinicians are reluctant to use TMP-SMZ in pregnant and breastfeeding HIV-infected women because of...
