Category Archives: Treatment
A meta-analysis of six placebo-controlled trials of thiazolidinedione therapy for HIV lipoatrophy
Objective: To determine the impact of thiazolidinediones (TZD) on changes in limb fat mass in HIV-infected individuals, particularly in those not receiving a thymidine analogue.Methods: Individual patient data from placebo-controlled,...
Screening for human immunodeficiency virus in adolescents and adults
Context: Human immunodeficiency virus infection affects 850,000 to 950,000 persons in the United States, with approximately 40,000 new infections annually. Diagnosis of unsuspected HIV infection could identify those who would...
Access to and utilisation of health services for the poor in Uganda: A systematic review of available evidence
Inequalities in the burden of disease and access to health care is a prominent concern in Uganda and other sub-Saharan African countries. This is a systematic review of socio-economic differences...
Optimal timing for antiretroviral therapy initiation in patients with HIV infection and concurrent cryptococcal meningitis
BACKGROUND: Currently, initiation of antiretroviral therapy (ART) in most patients with human immunodeficiency virus (HIV) infection is based on the CD4-positive-t-lymphocyte count. However, the point during the course of HIV...
The cost of treatment and care for people living with HIV infection: Implications of published studies, 1999-2008
Purpose of review: Increasing number of people living with HIV (PLHIV) will require expanded access to health services. Countries need robust and contemporary strategic information on the cost of care...
HIV-1 and intestinal helminth review update: Updating a Cochrane Review and building the case for treatment and has the time come to test and treat?
Intestinal helminth infection activates and dysregulates the immune system and impacts the host’s capacity to respond to illness. Such neglected tropical infections exact the greatest burden on resource-limited settings and...
Clinical trials of interactive computerized patient education: Implications for family practice
A systematic review of randomized clinical trials was conducted to evaluate the acceptability and usefulness of computerized patient education interventions. The Columbia Registry, MEDLINE, Health, BIOSIS, and CINAHL bibliographic databases...
Gender distribution of adult patients on highly active antiretroviral therapy (HAART) in Southern Africa: A systematic review
BACKGROUND: HIV and AIDS are significant and growing public health concerns in southern Africa. The majority of countries in the region have national adult HIV prevalence estimates exceeding 10 percent....
Systematic review of the safety of trimethoprim-sulfamethoxazole for prophylaxis in HIV-infected pregnant women: Implications for resource-limited settings
Daily prophylaxis with trimethoprim-sulfamethoxazole (TMP-SMZ) significantly decreases morbidity and mortality among people living with HIV. Some clinicians are reluctant to use TMP-SMZ in pregnant and breastfeeding HIV-infected women because of...
Complementary and alternative therapy (CAT) use and highly active antiretroviral therapy (HAART): Current evidence in the literature, 2000–2009
Aim and objective. To determine current evidence about the use of complementary and alternative medicine in the context of highly active antiretroviral therapy. The following objectives included identifying the risks...
