Category Archives: Treatment

Antiretroviral implants for treatment and prevention of HIV infection

2018

PURPOSE OF REVIEW: Poor adherence to oral antiretroviral formulations remains the major barrier to the success of long-term treatment and prevention strategies. Although a number of approaches have been developed...

A model-based comparative meta-analysis of the efficacy of dolutegravir-based and efavirenz-based regimens in HIV-infected patients

2019

Currently, combinations of typical types of antiretroviral agents have been adopted as chemotherapy for human immunodeficiency virus (HIV) infection, comprising two nucleoside analogue reverse transcriptase inhibitors plus one of a...

Mental health and substance use in HIV-infected adolescents

2018

PURPOSE OF REVIEW: Adolescents with HIV include both those infected perinatally and behaviourally. This population is confronted by normative challenges and HIV stressors as they move towards becoming increasingly independent...

Association between the UGT1A1*28 allele and hyperbilirubinemia in HIV-positive patients receiving atazanavir: A meta-analysis

2019

OBJECTIVES: The UGT1A1*28 allele in HIV-positive patients receiving atazanavir(ATV) might be associated with the risk of hyperbilirubinemia. Owing to mixed and inconclusive results, a meta-analysis was conducted to systematically summarize...

Self-disclosure of HIV status among youth living with HIV: A global systematic review

2019

Self-disclosure of HIV serostatus by youth has been considered an essential component of HIV prevention and medication adherence efforts. Therefore, a comprehensive investigation of disclosure goals, processes, and outcomes is...

Integration of care for HIV and opioid use disorder

2019

OBJECTIVE: We sought to identify optimal strategies for integrating HIV- and opioid use disorder-(OUD) screening and treatment in diverse settings. DESIGN: Systematic review. METHODS: We searched Ovid MEDLINE, PubMed, Embase,...

Antiretroviral concentration in hair as a measure for antiretroviral medication adherence: A systematic review of global literature

2019

This review aims to validate hair antiretroviral concentration (HAC) as a measure for antiretroviral medication adherence. This review included 31 studies that analyzed a total of 11 ARV drugs in...

Long-term effects of psychological interventions to improve adherence to antiretroviral treatment in HIV-infected persons: A systematic review and meta-analysis

2019

We examined the efficacy of psychological adherence-enhancing interventions (AEIs) compared with usual care in HIV-infected adults under antiretroviral treatment (ART) by focusing on adherence and clinical HIV markers as outcomes...

Challenges and support for quality of life of youths living with HIV/AIDS in schools and larger community in East Africa: A systematic review

2019

BACKGROUND: Youths living with HIV/AIDS (YLWHA) experience innumerable challenges within schools and the larger community. Nonetheless, these environments are potential sources of support for such youths. This review provides a...

Effectiveness of text messaging interventions on prevention, detection, treatment, and knowledge outcomes for sexually transmitted infections (STIs)/HIV: A systematic review and meta-analysis

2019

BACKGROUND: Rates of STIs continue to rise worldwide, and novel evidence-based interventions such as text messaging aimed at improving client services are needed. We conducted a meta-analysis to evaluate text...

Postpartum women living with HIV: Challenges related to retention in care, treatment adherence, and mental health

2018

Key take-home messages Postpartum women living with HIV may find it challenging to remain engaged in HIV care and achieve optimal adherence to antiretroviral medications. Late entry or suboptimal engagement...

Comparison of interventions to improve long-term medication adherence across different clinical conditions: A systematic review with network meta-analysis

2018

Background: Medication non-adherence has a dynamic, temporal and multifactorial nature with a significant impact on economic and clinical outcomes. Interventions to improve adherence are complex and require adaptation to patients’...

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