Category Archives: Prevention, Engagement and Care Cascade

Effectiveness of antiretroviral therapy in HIV-infected children under 2 years of age

2012

BACKGROUND: In the absence of antiretroviral therapy (ART), over 50% of HIV-infected infants progress to AIDS and death by 2 years of age. However, there are challenges to initiate ART...

Does increased hepatitis B vaccination dose lead to a better immune response in HIV-infected patients than standard dose vaccination: A meta-analysis?

2013

Human immunodeficiency virus (HIV)-infected patients often fail to produce protective antibodies to hepatitis B virus (HBV) vaccine. Some reports have suggested that increased-dose vaccination improves immune response to HBV vaccine...

Effectiveness of the 40 adolescent aids-risk reduction interventions: A quantitative review

1997

OBJECTIVE: (1) To review evaluations of Acquired Immunodeficiency Syndrome (AIDS) prevention interventions targeting adolescents to determine whether these efforts have been effective in reducing risk behaviors. (2) To examine the...

Synthesizing gender based HIV interventions in Sub-Sahara Africa: A systematic review of the evidence

2013

Gender is a critical component of HIV and sexual risk interventions. Examining the range, effectiveness and methodological rigor of studies that include a gender based component can inform current interventions...

Acceptability of HIV self-testing: A systematic literature review

2013

BACKGROUND: The uptake of HIV testing and counselling services remains low in risk groups around the world. Fear of stigmatisation, discrimination and breach of confidentiality results in low service usage...

Efficacy and safety of micafungin for invasive candida infections: A meta-analysis of randomized controlled trials

2012

Background Invasive fungal infections such as candidiasis and mold infections cause significant morbidity and mortality in seriously ill patients. Micafungin is an echinocandin antifungal agent with potent activity against most...

Adherence challenges with drugs for pre-exposure prophylaxis to prevent HIV infection

2014

Background There are 34 million people living with human immunodeficiency virus (HIV) worldwide and each year this number increases. Until a vaccine is discovered, the prevention of new HIV infections...

Protease inhibitor-associated QT interval prolongation

2011

OBJECTIVE: To evaluate the literature on protease inhibitor (PI)-associated QT interval prolongation and risk for torsade de pointes in patients infected by HIV. DATA SOURCES: Primary literature was identified through...

Impact of HIV-related stigma on treatment adherence: Systematic review and meta-synthesis

2013

Introduction: Adherence to HIV antiretroviral therapy (ART) is a critical determinant of HIV-1 RNA viral suppression and health outcomes. It is generally accepted that HIV-related stigma is correlated with factors...

Review and meta-analysis of couple-oriented interventions for chronic illness

2010

BACKGROUND: Evidence continues to build for the impact of the marital relationship on health as well as the negative impact of illness on the partner. Targeting both patient and partner...

Drug-related hypertension and resistance to antihypertensive treatment: A call for action

2011

Several drugs can cause hypertension and/or blunt the effect of antihypertensive treatment. They can exacerbate a previously well controlled hypertension and/or render it resistant to therapy. Accordingly, drugs represent a...

Mental health of HIV-seropositive women during pregnancy and postpartum period: A comprehensive literature review

2014

With growing numbers of HIV-seropositive (HIV+) women of child-bearing age and increased access to effective clinical protocols for preventing mother-to-child transmission (MTCT) of HIV, mental health-related factors have become increasingly...

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