Category Archives: Prevention, Engagement and Care Cascade
Etravirine (TMC-125): The evidence for its place in the treatment of HIV-1 infection
Introduction: Etravirine is a novel nonnucleoside reverse transcriptase inhibitor (NNRTI) specifically designed to suppress the replication of viruses resistant to the three currently approved NNRTIs efavirenz, nevirapine, and delavirdine. Aims:...
Safety of efavirenz in first-trimester of pregnancy: A systematic review and meta-analysis of outcomes from observational cohorts
Introduction: Data on efavirenz safety in first trimester pregnancy are conflicting. We conducted a systematic review and meta-analysis of the available evidence from observational cohorts., Methods: We ran duplicate searches...
HIV and HCV prevalence among entrants to methadone maintenance treatment clinics in China: A systematic review and meta-analysis
Background: Methadone maintenance treatment (MMT) was implemented in China since 2004. It was initiated in 8 pilot clinics and subsequently expanded to 738 clinics by the end of 2011. Numerous...
Efficacy and tolerability of initial antiretroviral therapy: A systematic review
OBJECTIVES: Successful antiretroviral therapy (ART) is largely attributed to the type of third drug. Guidelines recommend regimens without systematic review of all factors that might affect treatment success, such as...
Integration of HIV/AIDS services with maternal, neonatal and child health, nutrition, and family planning services
Background: The integration of HIV/AIDS and maternal, neonatal, child health and nutrition services (MNCHN), including family planning (FP) is recognized as a key strategy to reduce maternal and child mortality...
The efficacy of behavioral interventions in reducing HIV risk behaviors and incident sexually transmitted diseases in heterosexual African Americans
Objective:: To conduct a meta-analytic review of HIV interventions for heterosexual African Americans to determine the overall efficacy in reducing HIV-risk sex behaviors and incident sexually transmitted diseases and identify...
Directly observed antiretroviral therapy: A systematic review and meta-analysis of randomised clinical trials
BACKGROUND: Directly observed therapy has been recommended to improve adherence for patients with HIV infection who are on highly active antiretroviral therapy, but the benefit and cost-effectiveness of this approach...
Use of diet, nutritional supplements and exercise in HIV-infected patients receiving combination antiretroviral therapies: A systematic review
BACKGROUND: The use of combination antiretroviral therapy (cART) has improved the prognosis of HIV infection, but it has also been linked to a spectrum of body composition changes and metabolic...
Global epidemiology of injecting drug use and HIV among people who inject drugs: A systematic review
Background: Injecting drug use is an increasingly important cause of HIV transmission in most countries worldwide. Our aim was to determine the prevalence of injecting drug use among individuals aged...
