Category Archives: Prevention, Engagement and Care Cascade
Safety and efficacy of long-acting injectable agents for HIV-1: Systematic review and meta-analysis
Background: HIV-1 infection continues to affect global health. Although antiretrovirals can reduce the viral load or prevent HIV-1 infection, current drugs require daily oral use with a high adherence level. Long-acting...
Virtual avatars as a new tool for human immunodeficiency virus prevention among men who have sex with men: A narrative review
BACKGROUND AND OBJECTIVE: Human immunodeficiency virus (HIV) continues to affect sexual and gender minorities, predominantly men who have sex with men (MSM). Stigma, medical mistrust, and apprehension towards discussing sexual...
The risk of sexual transmission of HIV in individuals with low-level HIV viraemia: A systematic review
BACKGROUND: The risk of sexual transmission of HIV from individuals with low-level HIV viraemia receiving antiretroviral therapy (ART) has important public health implications, especially in resource-limited settings that use alternatives...
Adverse perinatal outcomes attributable to HIV in sub-Saharan Africa from 1990 to 2020: Systematic review and meta-analyses
Background: Maternal HIV infection and antiretroviral drugs (ARVs) are associated with increased risks of adverse perinatal outcomes. The vast majority of pregnant women living with HIV (WLHIV) reside in sub-Saharan Africa....
Characterizing blood pressure trajectories in people living with HIV following antiretroviral therapy: A systematic review
Objectives: The advent of antiretroviral therapy (ART) has reduced AIDS-related morbidity and mortality among people living with HIV (PLWH). Due to increased survival, PLWH have now been found to be at...
The use of azithromycin and pyrimethamine for treatment of cerebral toxoplasmosis in human immunodeficiency virus-infected patients: A systematic review
PURPOSE: Toxoplasma gondii is a parasite that is widely distributed around the globe and can cause brain inflammation, particularly in immunosuppressed patients such as those diagnosed with human immunodeficiency virus...
Integration of sexually transmitted infection and HIV pre-exposure prophylaxis services in sub-Saharan Africa: A scoping review
BACKGROUND: Persons living in sub-Saharan Africa (SSA) face disproportionate risk from overlapping epidemics of HIV and bacterial sexually transmitted infections (STIs). Pre-exposure prophylaxis (PrEP) for prevention is gradually being scaled...
Using a structural-ecological model to facilitate adoption of preexposure prophylaxis among latinx sexual minority men: A systematic literature review
Research has consistently shown that individual, interpersonal, community and structural factors influence the degree to which individuals’ access and utilize health care services, and these factors may play a role...
Pharmacotherapeutic interventions in people living with HIV undergoing solid organ transplantation: A scoping review
The pharmacotherapeutic management of people living with HIV (PLWHIV) undergoing solid organ transplantation (SOT) is clinically challenging, mainly due to the frequent occurrence of complex drug-drug interactions. Although various strategies...
Pre-exposure prophylaxis (PrEP) for HIV prevention among people who inject drugs: A global mapping of service delivery
BACKGROUND: The World Health Organization (WHO) recommends oral pre-exposure prophylaxis (PrEP) for all people at substantial risk of HIV as part of combination prevention. The extent to which this recommendation...
