Category Archives: Biomedical interventions
Reviewing PrEP’s effect on STI incidence among men who have sex with men —Balancing increased STI screening and potential behavioral sexual risk compensation
Though pre-exposure prophylaxis (PrEP) can prevent HIV acquisition, it provides no protection against bacterial sexually transmitted infections (STIs). PrEP use may increase STI acquisition due to sexual risk compensation, but...
Breastfeeding inequities in South Africa: Can enforcement of the WHO Code help address them? — A systematic scoping review
INTRODUCTION: Suboptimal breastfeeding rates in South Africa have been attributed to the relatively easy access that women and families have had to infant formula, in part as a result of...
Social media & PrEP: A systematic review of social media campaigns to increase PrEP awareness & uptake among young Black and Latinx MSM and women
Pre-exposure prophylaxis (PrEP) has been shown to be highly effective at reducing the risk of HIV. Despite efforts to employ various social marketing strategies to promote PrEP among young people...
Pre-exposure prophylaxis (PrEP) for HIV infection in cisgender and transgender women in the U.S.: A narrative review of the literature
Using a socioecological approach, this review describes the peer-reviewed literature on oral pre-exposure prophylaxis (PrEP) among both cisgender (cis women) and transgender women (trans women) in the U.S. A search...
Association between medical male circumcision and HIV risk compensation among heterosexual men: A systematic review and meta-analysis
BACKGROUND: Medical male circumcision (MMC) reduces HIV infection among heterosexual men. There are concerns MMC might prompt higher-risk sexual behaviours because of lower self-perceived risk of HIV infection. We reviewed...
Safety and pharmacokinetic profiles of long-acting injectable antiretroviral drugs for HIV-1 pre-exposure prophylaxis: A systematic review and meta-analysis of randomized trials
Objectives: To investigate the safety and pharmacokinetic profiles of long-acting injectable pre-exposure prophylaxis (LAI PrEP), notably cabotegravir (CAB-LA) and rilpivirine (RPV-LA), for the prevention of human immunodeficiency virus-1 (HIV-1) infection....
Changing knowledge and attitudes towards HIV Treatment-as-Prevention and “Undetectable=Untransmittable”: A systematic review
People on HIV treatment with undetectable virus cannot transmit HIV sexually (Undetectable=Untransmittable, U=U). However, the science of treatment-as-prevention (TasP) may not be widely understood by people with and without HIV...
The value of assessing self-reported and biological indicators of outcomes in evaluating HIV programs
PURPOSE OF REVIEW: In this manuscript, we present recent findings concerning concordance and discrepancy between biological measures and self-reports of these three outcomes of HIV programs: HIV status, adherence to...
Multiplexed technologies for sexually transmitted infections: Global evidence on patient-centered and clinical health outcomes
INTRODUCTION: Conventional care packages around screening for sexually transmitted infections (STIs) entail multiple clinic visits and precipitate losses to follow-up. To prevent these losses, multiplexed technologies for STIs (immunochromatographic tests/devices/assays...
The effect of tenofovir disoproxil fumarate on bone mineral density: A systematic review and meta-analysis
BACKGROUND: We conducted a systematic review and meta-analysis (CRD#42017070552) to quantify the impact of oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) on bone mineral density (BMD) and the risk of osteoporosis, low...
