Category Archives: Biomedical interventions

Behavioral interventions to enhance PrEP uptake among black men who have sex with men: A review

2019

In the United States, nearly 500,000 men who have sex with men (MSM) are at risk of contracting HIV. Men who have sex with men constitute 70% of all new...

Is co-location of services with HIV care associated with improved HIV care outcomes? A systematic review

2019

This systematic review identifies models of service co-location, a structural intervention strategy to remove barriers to HIV care and services, and examines their associations with HIV care outcomes. A cumulative...

A systematic review on the influence of HLA-B polymorphisms on HIV-1 mother-to-child transmission

2019

BACKGROUND: Mother-to-child-transmission (MTCT) is the main route of HIV-1 infection in children. Genetic studies suggest HLA-B alleles play an important role on HIV-1 transmission, progression, and control of HIV-1 infection....

Does male circumcision reduce women’s risk of sexually transmitted infections, cervical cancer, and associated conditions?

2019

Background: Male circumcision (MC) is proven to substantially reduce men’s risk of a number of sexually transmitted infections (STIs). We conducted a detailed systematic review of the scientific literature to...

The efficacy of post-exposure prophylaxis (PEP) for HIV

2019

Key take-home messages PEP initiated soon after exposure can reduce the risk of HIV seroconversion after occupational and non-occupational exposures, provided adherence to medications is sufficient. Evidence suggests that individuals...

The impact of location on implementation of HIV/STI prevention interventions among LGBTQ communities

2019

Key take-home messages The characteristics of a location, including segregation, community-level stigma, and infrastructural resources, may influence HIV service utilization and the HIV continuum of care among men who have...

HIV-related care for transgender people: A systematic review of studies from around the world

2019

RATIONALE: Transgender people face unique challenges, such as structural, interpersonal, and individual vulnerabilities to chronic diseases. Stigma and prejudice may hamper their access to health care and prevent their inclusion...

Optimizing pediatric dosing recommendations and treatment management of antiretroviral drugs utilizing therapeutic drug monitoring data in children living with HIV

2019

INTRODUCTION: This review summarises the current dosing recommendations for antiretroviral drugs (ARVs) in the international pediatric guidelines of the World Health Organisation (WHO), US Department of Health and Human Services...

Retest and treat: A review of national HIV retesting guidelines to inform elimination of mother-to-child HIV transmission (EMTCT) efforts

2019

INTRODUCTION: High maternal HIV incidence contributes substantially to mother-to-child HIV transmission (MTCT) in some settings. Since 2006, HIV retesting during the third trimester and breastfeeding has been recommended by the...

Elimination of HIV transmission through novel and established prevention strategies among people who inject drugs

2018

Despite the effectiveness of existing HIV prevention strategies for people who inject drugs (PWID), uncontrolled outbreaks of HIV among this group are common and occur around the world. In this...

Maternal immunisation to improve the health of HIV-exposed infants

2018

HIV-exposed but uninfected (HEU) infants are at an increased risk of many infectious diseases that can contribute to the high mortality seen among HEU children. Maternal immunisation could be a...

Incidence of sexually transmitted infections in men who have sex with men and who are at substantial risk of HIV infection – A meta-analysis of data from trials and observational studies of HIV pre-exposure prophylaxis

2018

BACKGROUND: Men who have sex with men (MSM) and who engage in condomless anal intercourse with casual partners are at high risk of acquiring sexually transmitted infections (STIs), but reliable...

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