Category Archives: Biomedical interventions
The pharmacogenetics of efavirenz metabolism in children: The potential genetic and medical contributions to child development in the context of long-term ARV treatment
Efavirenz (EFV) is a well-known, effective anti-retroviral drug long used in first-line treatment for children and adults with HIV and HIV/AIDS. Due to its narrow window of effective concentrations, between...
What is the most appropriate induction regimen for the treatment of HIV-associated Cryptococcal meningitis when the recommended regimen is not available? Evidence from a network meta-analysis
Aims: Our object was to find the most appropriate, most effective, and most readily available of four induction regimens for HIV-associated cryptococcal meningitis (CM) (Regimen A: 1 week of AmB...
Attributes of HIV infection over decades (1982–2018): A systematic review and meta-analysis
Understanding the risk factors for HIV infection is the foundation of successful preventive strategies, which must bundle sociocultural, behavioural and biomedical interventions to halt disease transmission. We aimed in this...
Using digital communication technology to increase HIV testing among men who have sex with men and transgender women: Systematic review and meta-analysis
BACKGROUND: HIV continues to disproportionately affect men who have sex with men (MSM) and transgender women (TW). Undiagnosed HIV is a major driver of HIV transmission rates, and increasing the...
Oral pre-exposure prophylaxis (PrEP) continuation, measurement, and reporting: A systematic review and meta-analysis
OBJECTIVE: To appropriately plan for rollout and monitor impact of oral pre-exposure prophylaxis (PrEP) it is important to understand PrEP continuation and come to a consensus on how best to...
Effects of time of initiation of antiretroviral therapy in the treatment of patients with HIV/TB co-infection: A systemic review and meta-analysis
This systemic review and meta-analysis aimed to investigate the burden of tuberculosis immune reconstitution syndrome (TB-IRIS) and associated mortality to highlight the importance of future direction in preventing and treatment...
A review of usability evaluation methods and their use for testing eHealth HIV interventions
PURPOSE OF REVIEW: To provide a comprehensive review of usability testing of eHealth interventions for HIV. RECENT FINDINGS: We identified 28 articles that assessed the usability of eHealth interventions for...
Home-based care, the missing link in caring of patients living with HIV/AIDS and their family members: A narrative review
Inconsistencies between the number of patients, qualified caregivers and lack of adequate services and resources in the healthcare systems for people living with HIV/AIDS have led to the idea of...
Direct-acting antivirals for HCV treatment in older patients: A systematic review and meta-analysis
The advent of highly effective and well-tolerated direct antiviral antivirals (DAAs) has dramatically changed the landscape of chronic hepatitis C. The effect of DAAs in older adults is difficult to...
The effectiveness of electronic health interventions for promoting HIV-preventive behaviors among men who have sex with men: Meta-analysis based on an integrative framework of design and implementation features
BACKGROUND: The disproportionately high prevalence of HIV among men who have sex with men (MSM) is a global concern. Despite the increasing utilization of electronic health (eHealth) technology in the...
