Category Archives: Biomedical interventions
Cost-effectiveness of HIV prevention interventions in sub-Saharan Africa: A systematic review
Background: Sub-Saharan Africa carries the highest HIV burden globally. It is important to understand how interventions cost-effectively fit within guidelines and implementation plans, especially in low- and middle-income settings. We reviewed...
Factors affecting pre-exposure prophylaxis implementation for women in the United States: A systematic review
Oral HIV pre-exposure prophylaxis (PrEP) is a highly effective pill that HIV-negative individuals can take once daily to prevent HIV infection. Although PrEP is a private, user-controlled method that empowers...
A realist review of infant feeding counselling to increase exclusive breastfeeding by HIV-positive women in sub Saharan-Africa: What works for whom and in what contexts
BACKGROUND: The most recent World Health Organization (WHO) guidelines on Human Immunodeficiency Virus (HIV) and infant feeding promotes exclusive breastfeeding (EBF) in resource limited settings for the prevention of mother...
HIV pre-exposure prophylaxis (PrEP) awareness and acceptability among trans women: a review
Transgender (trans) women are disproportionally burdened by the HIV epidemic due to complex structural, psychosocial and biological factors. HIV pre-exposure prophylaxis (PrEP) is a biomedical prevention approach for people at...
Is co-location of services with HIV care associated with improved HIV care outcomes? A systematic review
This systematic review identifies models of service co-location, a structural intervention strategy to remove barriers to HIV care and services, and examines their associations with HIV care outcomes. A cumulative...
A systematic review on the influence of HLA-B polymorphisms on HIV-1 mother-to-child transmission
BACKGROUND: Mother-to-child-transmission (MTCT) is the main route of HIV-1 infection in children. Genetic studies suggest HLA-B alleles play an important role on HIV-1 transmission, progression, and control of HIV-1 infection....
Does male circumcision reduce women’s risk of sexually transmitted infections, cervical cancer, and associated conditions?
Background: Male circumcision (MC) is proven to substantially reduce men’s risk of a number of sexually transmitted infections (STIs). We conducted a detailed systematic review of the scientific literature to...
The impact of location on implementation of HIV/STI prevention interventions among LGBTQ communities
Key take-home messages The characteristics of a location, including segregation, community-level stigma, and infrastructural resources, may influence HIV service utilization and the HIV continuum of care among men who have...
HIV-related care for transgender people: A systematic review of studies from around the world
RATIONALE: Transgender people face unique challenges, such as structural, interpersonal, and individual vulnerabilities to chronic diseases. Stigma and prejudice may hamper their access to health care and prevent their inclusion...
Optimizing pediatric dosing recommendations and treatment management of antiretroviral drugs utilizing therapeutic drug monitoring data in children living with HIV
INTRODUCTION: This review summarises the current dosing recommendations for antiretroviral drugs (ARVs) in the international pediatric guidelines of the World Health Organisation (WHO), US Department of Health and Human Services...
