Category Archives: Biomedical interventions
Starter packs versus full prescription of antiretroviral drugs for postexposure prophylaxis: A systematic review
BACKGROUND: The provision of starter packs for human immunodeficiency virus postexposure prophylaxis (PEP) is practiced in many settings to facilitate rapid initiation by nonexperts and encourage adherence. However, the impact...
Barriers to successful implementation of prevention-of-mother-to-child-transmission (PMTCT) of HIV programmes in Malawi and Nigeria: A critical literature review study
Mother-to-child-transmission (MTCT) of HIV still remains a significant route of new HIV infection in children in Malawi and Nigeria, despite the introduction of Prevention-of-Mother-to-Child-Transmission (PMTCT) of HIV programmes in both...
Choice of antiretroviral drugs for postexposure prophylaxis for children: A systematic review
BACKGROUND: This systematic review aimed to assess the safety and efficacy of antiretroviral options for postexposure prophylaxis (PEP). Recognizing the limited data on the safety and efficacy of antiretroviral drugs...
Universal voluntary HIV testing in antenatal care settings: A review of the contribution of provider-initiated testing & counselling
Objective To assess the contribution of provider-initiated testing and counselling (PITC) to achieving universal testing of pregnant women and, from available data on components of PITC, assess whether PITC adoption...
Experiences integrating delivery of maternal and child health services with childhood immunization programs: Systematic review update
BACKGROUND: The World Health Organization and the United Nations Children’s Fund promote integration of maternal and child health (MCH) and immunization services as a strategy to strengthen immunization programs. We...
The uptake of integrated perinatal prevention of mother-to-child HIV transmission programs in low- and middle-income countries: A systematic review
BACKGROUND: The objective of this review was to assess the uptake of WHO recommended integrated perinatal prevention of mother-to-child transmission (PMTCT) of HIV interventions in low- and middle-income countries. METHODS...
The evolving design and methods for trials evaluating the safety of candidate vaginal microbicides: A systematic review
Vaginal preexposure prophylaxis is a promising biomedical tool for HIV prevention. Although guidelines for the clinical assessment of microbicides are available, validated markers for product safety are lacking. To inform...
Hormonal contraceptive use and female-to-male HIV transmission: A systematic review of the epidemiologic evidence
OBJECTIVE: To systematically review epidemiologic evidence assessing whether hormonal contraception alters the risk of HIV transmission from an HIV-positive woman to an HIV-negative male partner. DESIGN: Systematic review. METHODS: We...
