Category Archives: Health Systems
Efficacy and safety of contemporary dual-drug antiretroviral regimens as first-line treatment or as a simplification strategy: A systematic review and meta-analysis
BACKGROUND: Some guidelines recommended two-drug antiretroviral therapies as alternative regimens to triple therapy in selected patients with the aim of reducing drug burden and toxicity and preserving future treatment options....
A systematic review on confidentiality, disclosure, and stigma in the United States: Lessons for HIV care in pregnancy from reproductive genetics
The fields of HIV care in pregnancy and reproductive genetics have always been ‘exceptional’ in that patients are highly concerned about the potential for stigma and the corresponding need for...
Policing practices as a structural determinant for HIV among sex workers: A systematic review of empirical findings
INTRODUCTION: Sex workers are disproportionately infected with HIV worldwide. Significant focus has been placed on understanding the structural determinants of HIV and designing related interventions. Although there is growing international...
The use of social networking applications of smartphone and associated sexual risks in lesbian, gay, bisexual, and transgender populations: A systematic review
The use of social networking applications (apps) on smartphones has the potential to impact sexual health and behaviour. This was the first systematic review to critically appraise and summarize the...
The effectiveness of mobile phone text messaging in improving medication adherence for patients with chronic diseases: A systematic review
CONTEXT: Medication non-adherence is a commonly observed problem in the self-administration of treatment, regardless of the disease type. Text messaging reminders, as electronic reminders, provide an opportunity to improve medication...
Option B+ for the prevention of mother-to-child transmission of HIV infection in developing countries: A review of published cost-effectiveness analyses
OBJECTIVE: To review the published literature on the cost effectiveness of Option B+ (lifelong antiretroviral therapy) for preventing mother-to-child transmission (PMTCT) of HIV during pregnancy and breastfeeding to inform decision...
Dynamic transmission economic evaluation of infectious disease interventions in low- and middle-income countries: A systematic literature review
Economic evaluation using dynamic transmission models is important for capturing the indirect effects of infectious disease interventions. We examine the use of these methods in low- and middle-income countries, where...
Incidence of opportunistic infections and the impact of antiretroviral therapy among HIV-infected adults in low- and middle-income countries: A systematic review and meta-analysis
BACKGROUND: To understand regional burdens and inform delivery of health services, we conducted a systematic review and meta-analysis to evaluate the effect of antiretroviral therapy (ART) on incidence of key...