SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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The worldwide prevalence of anxiety in acquired immune deficiency syndrome patients: A systematic review and meta-analysis

2021

Background: Anxiety affects social, economic, and physical aspects of daily life in patients with AIDS. Therefore, it is necessary to take preventive measures and design plans to maintain their general...

Pre-exposure prophylaxis uptake, adherence, and persistence: A narrative review of interventions in the U.S

2021

Since 2012, HIV pre-exposure prophylaxis (PrEP) has been available to prevent HIV transmission; yet, uptake, adherence, and persistence to PrEP have been suboptimal. This narrative review examines the latest interventions...

MR spectroscopy in HIV associated neurocognitive disorder in the era of cART: A review

2021

Neuroimaging has been a critical tool for understanding the neuropathological underpinnings observed in HIV. The pathophysiology of HAND is chiefly driven by neuroinflammation. Despite adhering to cART, low levels of...

The prevalence of thrombocytopenia and leucopenia among people living with HIV/AIDS in Ethiopia: A systematic review and meta-analysis

2021

INTRODUCTION: Thrombocytopenia and leucopenia are frequently encountered hematological disorders among people living with HIV/AIDS. This systematic review and meta-analysis were aimed to indicate the national prevalence of thrombocytopenia and leucopenia...

Sex differences in HIV testing among older adults in sub-Saharan Africa: A systematic review

2021

BACKGROUND: Despite being sexually active and engaging in risky sexual behaviours similar to young adults, older adults (50 years or older) are less likely to receive HIV testing, and disaggregated...

Clinical consequences of asymptomatic cytomegalovirus in treated human immunodeficency virus infection

2021

PURPOSE OF REVIEW: Despite antiretroviral therapy (ART)-mediated viral suppression, people with human immunodeficiency virus (HIV) (PWH) have increased morbidity and mortality. Immune activation and inflammation persist on ART and predict...

Human Immunodeficiency Virus Infection and Incident Heart Failure: A Meta-analysis of Prospective Studies

2021

OBJECTIVES: To systematically analyze available prospective evidence on the association between HIV infection and incident heart failure (HF). METHODS: A systematic search of PubMed, EMBASE, Web of Science, and manual...

Hepatitis B virus genetic multiplicity and the associated HBV lamivudine resistance mutations in HBV/HIV co-infection in Western Kenya: A review article

2021

Background: Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) co-infections are common as the two viruses use same routes of transmission. Studies show that HIV infection modifies the natural course...

Experienced homophobia and HIV infection risk among U.S. gay, bisexual, and other men who have sex with men: A meta-analysis

2021

Purpose: Experienced homophobia-negative treatment and perceptions that gay, bisexual, and other men who have sex with men (MSM) encounter because of their sexual orientations-may promote HIV infection among MSM. We conducted...

A narrative systematic review of sexualised drug use and sexual health outcomes among LGBT people

2021

INTRODUCTION: Chemsex is a specific form of sexualised drug use (SDU) that is an emerging public health issue among men who have sex with men (MSM). Although the recent focus...

Adjunct therapy for CD4(+) T-cell recovery, inflammation and immune activation in people living With HIV: A systematic review and meta-analysis

2021

Background: HIV infection results in immune homeostasis perturbations, which is characterized by CD4(+) T-cell depletion, immune activation, and inflammation. Effective antiretroviral therapy (ART) does not fully restore immunologic and clinical...

Association of sexual health interventions With sexual health outcomes in Black adolescents: A systematic review and meta-analysis

2021

Importance Black adolescents are at increased risk of contracting HIV and other sexually transmitted infections (STIs) and experiencing unplanned pregnancy. Although sexual health interventions aimed at decreasing these risks exist,...

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