SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Screening adolescents for sensitive health topics in primary care: A scoping review

2021

We sought to aggregate common barriers and facilitators to screening adolescents for sensitive health topics (e.g., depression, chlamydia) in primary care, as well as those that are unique to a...

The HIV care cascade in sub-Saharan Africa: Systematic review of published criteria and definitions

2021

INTRODUCTION: The HIV care cascade examines the attrition of people living with HIV from diagnosis to the use of antiretroviral therapy (ART) and suppression of viral replication. We reviewed the...

Prevalence of HIV and HCV among injecting drug users in three selected WHO-EMRO countries: A meta-analysis

2021

BACKGROUND: HIV and Hepatitis C Virus (HCV) infections are responsible for a significant burden of mortality and morbidity, particularly in developing countries. This study sought to determine the prevalence of...

Health-related quality of life in patients with different diseases measured with the EQ-5D-5L: A systematic review

2021

Background: The EQ-5D-5L is a generic preference-based questionnaire developed by the EuroQol Group to measure health-related quality of life (HRQoL) in 2005. Since its development, it has been increasingly applied...

Mobile health interventions for HIV/STI prevention among youth in low- and middle-income countries (LMICs): A systematic review of studies reporting implementation outcomes

2021

Background Advances and proliferation of technologies such as mobile phones may provide opportunities to improve access to HIV/STI services and reach young people with high risk for HIV and STI....

Social and behavioral impacts of COVID-19 on people living with HIV: Review of the first year of research

2021

PURPOSE OF THE REVIEW: The SARS-CoV-2 (COVID-19) pandemic brought unprecedented social change with the most severe impacts on the most vulnerable populations, including people living with HIV (PLWH). This review...

A review of public health, social and ethical implications of voluntary medical male circumcision programs for HIV prevention in sub-Saharan Africa

2021

Ideally, the benefits of public health interventions should outweigh any associated harms, burdens, and adverse unintended consequences. The intended benefit of voluntary medical male circumcision (VMMC) programs in eastern and...

Effectiveness of ezetimibe in human immunodeficiency virus patients treated for hyperlipidaemia: A systematic review and meta-analysis

2021

Objective: Systematic review and meta-analysis of lipid outcomes for human immunodeficiency virus (HIV)-positive or HIV-infected patients treated with ezetimibe. Methods: We conducted a literature search from 1946 to 2021 for trials studying...

Prescribing intranasal steroids in HIV-positive patients: Systematic review of the literature

2021

BACKGROUND: There are significant drug-drug interactions between human immunodeficiency virus antiretroviral therapy and intranasal steroids, leading to high serum concentrations of iatrogenic steroids and subsequently Cushing’s syndrome. METHOD: All articles...

Low inducibility of latent human immunodeficiency virus type 1 proviruses as a major barrier to cure

2021

The latent reservoir for human immunodeficiency virus type 1 (HIV-1) in resting CD4+ T cells is a major barrier to cure. The dimensions of the reservoir problem can be defined...

Mental health symptoms associated with sexualized drug use (chemsex) among men who have sex with men: A systematic review

2021

BACKGROUND: Sexualized drug use (SDU), also known as chemsex, refers to the use of psychoactive substances for sexual purposes among men who have sex with men (MSM), which has been...

Isoniazid preventive therapy plus antiretroviral therapy for the prevention of tuberculosis: A systematic review and meta-analysis of individual participant data

2021

Background: Isoniazid preventive therapy prevents active tuberculosis in people with HIV, but previous studies have found no evidence of benefit in people with HIV who had a negative tuberculin skin...

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