SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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The prevalence of low-level viraemia and its association with virological failure in people living with HIV: A systematic review and meta-analysis

2025

Low-level viraemia (LLV) following antiretroviral therapy (ART) in people living with HIV (PLWH) has not received sufficient attention. To the determine the prevalence of LLV and its association with virological...

The impact of place of residence on antiretroviral therapy adherence: A systematic review and meta-analysis

2025

Objective: There is evidence of geographical variation in HIV coverage and antiretroviral therapy (ART) adherence, and studies have investigated how the place of residence of people living with HIV (PLWH) influences...

HIV prevention interventions and research in the philippines for high-risk populations: Proposals from a scoping review of contributing cactors

2025

Despite a global decrease in HIV cases and efforts to reduce HIV incidence in the country, the Philippines has an increasing HIV incidence rate, which is the highest in the...

Meta-analysis of TB & HIV co-infection mortality rate in sub-Saharan African children, youth, and adolescents

2025

Background Despite the effectiveness of antiretroviral treatment (ART) in reducing morbidity and mortality, children and adolescents with co-infections face an elevated risk of death due to their young age and...

Transitioning to adult HIV care: Challenges and evidence-based practices

2025

Key take-home messages

Evaluating the safety and efficacy of malaria preventive measures in pregnant women with a focus on HIV status: A systematic review and network meta-analysis

2025

Background and Objectives: Malaria poses significant threats to pregnant women, particularly in endemic regions. Preventive measures against it include insecticide-treated bed nets, intermittent preventive treatment, and various supplements. We aimed...

Association between baseline HIV-1 DNA levels and clinical outcomes in people living with HIV: A meta-analysis of cohort studies

2025

This systematic review and meta-analysis evaluated the effect of digital communication tools (e.g., text message reminders) on improving daily oral HIV pre-exposure prophylaxis (PrEP) adherence. Searching PubMed, Embase, Web of...

Tetracycline-resistant Neisseria gonorrhoeae global estimates-impacts on doxycycline post-exposure prophylaxis implementation and monitoring: A systematic review

2025

Objectives Doxycycline post-exposure prophylaxis (doxyPEP) can reduce incident sexually transmitted infections including gonorrhoea for MSM and transgender women. Its effectiveness depends on the level of tetracycline resistance in Neisseria gonorrhoeae, which...

Performance of adherence measures for oral, tenofovir-based HIV pre-exposure prophylaxis: A systematic review

2025

Accurate adherence measures to HIV pre-exposure prophylaxis (PrEP) are essential for identifying individuals with low adherence and providing tailored support. This systematic review summarizes evidence on the performance of PrEP...

Mortality and associated factors among children with the double burden of human immunodeficiency virus and tuberculosis in African countries: A systematic review and meta-analysis

2025

Introduction The dual burden of Human Immunodeficiency Virus (HIV) and Tuberculosis (TB) in children is leading to significant mortality. Although primary studies have reported wide ranges of mortality rates among...

Marriage and Steady Relationships with Women in Men Who Have Sex with Men in Sub-Saharan Africa: A Mixed-Method Systematic Review and Meta-analyses

2025

High HIV prevalence in Sub-Saharan African (SSA) in men who have sex with men (MSM) leads to greater risk for their wives and other steady female partners because of prolonged...

Chronic kidney disease among people living with HIV on TDF based regimen: A systematic review and meta-analysis

2025

INTRODUCTION: Chronic kidney disease is a major public health concern among people living with human immunodeficiency virus (PLWHIV) who are taking tenofovir disoproxil fumarate-based regimen. Despite the available evidence showing...

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