SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Natural resistance to HIV infection: Role of immune activation

2025

INTRODUCTION: Although repeated exposure to HIV-1 can result in infection, some individuals remain seronegative without clinical or serologic evidence of infection; these individuals are known as HIV-1-exposed seronegative individuals. This...

Prevalence of HHV-6 detection among people living with HIV: A systematic review and meta-analysis

2025

Human herpesvirus 6 (HHV-6) is a ubiquitous virus with significant implications for immunocompromised individuals, particularly people living with HIV (PLWH). This study aimed to estimate the prevalence of HHV-6 detection...

Health-related stigma among Indigenous peoples in Canada: A scoping review

2025

BACKGROUND: Indigenous communities in Canada are disproportionately affected by health conditions linked to stigma, warranting the attention of researchers seeking to understand this culturally-determined phenomenon. This study explores the scope...

Health educational interventions for adolescents living with HIV: A scoping review

2025

BACKGROUND: Adolescents living with HIV face unique challenges as they gain greater independence while transitioning into adulthood. They must adjust their self-management activities and take primary responsibility for their health,...

Effect of human immunodeficiency virus self-testing (HIVST) on HIV and STI testing uptake among men who have sex with men (MSM): A systematic review and meta-analysis of randomized controlled trials

2025

Objectives: The objective of this review was to assess the effectiveness of HIVST in terms of increasing HIV testing, early detection of HIV, and sexually transmitted infections among MSM via...

A global meta-analysis of gonorrhoea and chlamydia prevalence among men who have sex with men from 2000 to 2022

2025

IntroductionWe conducted a global systematic review and meta-analysis of gonorrhoea and chlamydia among men who have sex with men (MSM) from 2000 to 2022.MethodsWe searched four databases to identify studies...

The impact of HPV/HIV co-infection on immunosuppression, HPV genotype, and cervical cancer biomarkers

2025

BACKGROUND: Human papillomavirus (HPV) and human immunodeficiency virus (HIV) co-infection present a significant impact on women’s health globally, especially in immunocompromised individuals. HIV-induced immunosuppression promotes the persistence of high-risk HPV...

Growth and body composition of adolescents and young adults with perinatal HIV infection: A systematic review and meta-analysis

2025

Introduction: Approximately 1.3 million pregnancies are exposed to HIV perinatally each year, with transmission rates ranging from 4 to 21%, despite 85% antiretroviral therapy (ART) coverage among pregnant women. While ART...

Assessment tools for evaluating pharmacy students’ knowledge on HIV prophylaxis: A scoping review

2025

OBJECTIVES: This study aimed to identify and evaluate instruments used to measure pharmacy students’ knowledge of HIV prophylaxis, focusing on both preexposure prophylaxis (PrEP) and postexposure prophylaxis. METHODS: A systematic...

Breast cancer clinical characteristics, management, and outcomes in women living with HIV/AIDS globally: A systematic review and meta-analysis

2025

Although associations between HIV and breast cancer (BC) have been investigated, the global literature remains inconsistent regarding clinical features and outcomes in HIV-positive patients. This study aims to clarify the...

Reporting and handling of missing data in published studies of co-morbid hypertension and diabetes among people living with HIV/AIDS: A systematic review

2025

BACKGROUND: As hypertension and diabetes emerge as co-morbidities among people living with HIV/AIDS (PLWH), the need for robust epidemiological research to inform policy and action is imperative. Proper reporting and...

Cabotegravir plus rilpivirine injection for virally suppressed persons with HIV-1 infection: A systematic review and meta-analysis of randomized controlled trials

2025

Purpose: This study evaluated the efficacy and safety of cabotegravir/rilpivirine long-acting formulation compared to oral standard of care at 48 and 52 weeks. Method: We conducted an electronic search (2005-2024) across databases...

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