SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Time to HIV viral rebound and frequency of post-treatment control after analytical interruption of antiretroviral therapy: An individual data-based meta-analysis of 24 prospective studies

2025

The only current strategy to test efficacy of novel interventions for sustained HIV control without antiretroviral therapy (ART) among people with HIV (PWH) is through an analytical treatment interruption (ATI)....

Growth of children who are HIV-exposed but uninfected: A systematic review and meta-analysis

2025

BACKGROUND: Pooled analyses summarising long-term growth outcomes in children who are HIV-exposed uninfected (HEU) compared with children who are HIV-unexposed (HU) are lacking. We aimed to summarise the existing literature...

Climate change and extreme weather events and linkages with HIV outcomes: Recent advances and ways forward

2025

PURPOSE OF REVIEW: Discuss the recent evidence on climate change and related extreme weather events (EWE) and linkages with HIV prevention and care outcomes. RECENT FINDINGS: We identified 22 studies...

Barriers and facilitators to accessing sexual and reproductive health services for people with severe mental illness: A systematic review

2025

PURPOSE: Despite increased prevalence of sexual and reproductive health problems among people with severe mental illness (SMI), uptake of sexual and reproductive healthcare in this group is poor. The reasons...

The role of digital tools in enhancing antiretroviral therapy adherence among adolescents and young adults with HIV: A systematic review of randomized controlled trials

2025

Background: Adolescents and Young Adults (AYA) face challenges in maintaining antiretroviral therapy (ART) adherence, necessitating the need for targeted and innovative interventions. Digital tools have shown potential in improving ART adherence...

Adolescents’ sexual health during the COVID-19 outbreak: A systematic review

2025

BACKGROUND AND AIMS: The COVID-19 pandemic has greatly disrupted adolescents’ access to sexual health services, resulting in a decline in their overall sexual well-being. This systematic review explored adolescent sexual...

Aetiology of fever of unknown origin in people living with HIV: A systematic review and meta-analysis

2025

Introduction: Fever of unknown origin (FUO) in people living with HIV presents a significant diagnostic challenge due to its broad range of potential aetiologies. Objective: The aims of this study were to...

Mapping the gut microbiota composition in the context of Raltegravir, dolutegravir, and bictegravir—A scoping review

2025

(1) Background: Second-generation integrase strand transfer inhibitors (INSTIs) are now the preferred first-line therapies for human immunodeficiency virus (HIV). However, concerns regarding their side effects, such as weight gain and...

Implementation of trauma-informed care into clinical HIV prevention and care settings: A decade of limited progress

2025

PURPOSE OF THE REVIEW: Trauma is common among people living with or at risk for HIV and associated with increased HIV risk and worse HIV care outcomes. Trauma-informed care (TIC)...

Cardiovascular disease and its risk factors among people living with HIV: A systematic review and meta-analysis

2025

This meta-analysis aimed to quantify the latest cardiovascular disease (CVD) incidence rate and assess the impact of risk factors among people living with HIV (PLWH). We searched PubMed, Embase, Web...

Burden of depression among HIV caregivers in India: A systematic review and meta-analysis

2025

Caregivers of individuals living with HIV face significant mental health challenges, with depression being the most common. Despite global research highlighting this burden, studies specific to the Indian context are...

What are the risk factors of non-fatal overdose among persons who use opioids? A systematic review and meta-analysis

2025

Introduction: Non-fatal opioid overdose (NFOD) is a concerning public health issue that is a risk factor for subsequent fatal overdose. Methods: This systematic review aimed to evaluate all the previous literature using...

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