SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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HIV-1 drug resistance detected by next-generation sequencing among ART-naive individuals: A systematic review and meta-analysis

2024

Background: There are an increasing number of articles focused on the prevalence and clinical impact of pretreatment HIV drug resistance (PDR) detected by Sanger sequencing (SGS). PDR may contribute to...

Prevalence of emergent dolutegravir resistance mutations in people living with HIV: A rapid scoping review

2024

BACKGROUND: Dolutegravir (DTG) is a cornerstone of global antiretroviral (ARV) therapy (ART) due to its high efficacy and favorable tolerability. However, limited data exist regarding the risk of emergent integrase...

Multimodal approach to neurocognitive function in people living with HIV in the cART era: A comprehensive review

2024

Combination antiretroviral treatment (cART) has revolutionized the management of human immunodeficiency virus (HIV) and has markedly improved the disease burden and life expectancy of people living with HIV. HIV enters...

Analysis and mapping of global research publications on point-of-care testing for infectious diseases

2024

RATIONALE: This study presents the first comprehensive analysis and mapping of scientific research on point-of-care testing (POCT) in infectious diseases, filling a gap in understanding the evolving landscape of this...

Low clinical impact of HIV drug resistance mutations in oral pre-exposure prophylaxis: A systematic review and meta-analysis

2024

Introduction Despite the widespread use of pre-exposure prophylaxis (PrEP) in preventing human immunodeficiency virus (HIV) transmission, scant information on HIV drug resistance mutations (DRMs) has been gathered over the past...

The childbirth experiences of pregnant women living with HIV virus: Scoping review

2024

OBJECTIVE: Understand and explore the childbirth experiences of pregnant women living with HIV (PWLWHIV). With the advent of several measures to decrease the intrapartum HIV infection and a strong emphasis...

HIV PrEP coverage among Black adults: A concept analysis of the inequities, disparities, and implications

2024

BACKGROUND: Significant racial disparities exist in HIV pre-exposure prophylaxis (PrEP) coverage in the United States (U.S), with Black individuals experiencing seven times higher new HIV infection rates compared to their...

Adverse perinatal outcomes associated with different classes of antiretroviral drugs in pregnant women living with HIV: A systematic review and meta-analysis

2024

OBJECTIVE: Women living with HIV (WLHIV) are at increased risk of adverse perinatal outcomes compared to HIV-negative women, despite antiretroviral therapy (ART). There is evidence that the risk of adverse...

Management of low-level HIV viremia during antiretroviral therapy: Delphi consensus statement and appraisal of the evidence

2024

Objective While antiretroviral therapy (ART) is highly effective, detection of low levels of HIV-1 RNA in plasma is common in treated individuals. Given the uncertainties on the topic, we convened...

The impact of analytical treatment interruptions and trial interventions on time to viral re-suppression in people living with HIV restarting ART in cure-related clinical studies: A systematic review and meta-analysis

2024

INTRODUCTION: To assess the effectiveness of novel HIV curative strategies, “cure” trials require periods of closely monitored antiretroviral therapy (ART) analytical treatment interruptions (ATIs). We performed a systematic review and...

Systematic review and meta-analysis of retention and disengagement after initiation on antiretroviral therapy in low- and middle-income countries after the introduction of universal test and treat policies

2024

BACKGROUND: We previously published a systematic review evaluating retention in care after antiretroviral therapy treatment initiation among adults in low- and middle-income countries. We estimated retention at 36 months to...

Linkage to care and prevention after HIV self-testing: A systematic review and meta-analysis

2024

INTRODUCTION: Effective linkage to prevention and care is a crucial step following HIV testing services. This systematic review aimed to determine the proportion of individuals linked to prevention and care...

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