SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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HIV testing during systematic screening for tuberculosis among household contacts in high-tuberculosis burden settings: A systematic review and meta-analysis

2026

BACKGROUND: Tuberculosis household contacts are at elevated risk of HIV, and systematic screening for tuberculosis is an opportunity for people to know their status. We aimed to assess the coverage...

Models of primary health care for people living with HIV

2026

Key take-home messages

Barriers and facilitators to the diagnosis of HIV and other STIs in primary care within publicly funded healthcare systems: A systematic review of qualitative studies

2026

BACKGROUND: Human immunodeficiency virus (HIV) and other sexually transmitted infections (STI) are a major public health concern. Primary care (PC) is the ideal setting for their diagnosis. Designing effective strategies...

Rapid diagnostic tests, laboratory-based immunoassay and nucleic acid testing strategies for long-acting injectable pre-exposure prophylaxis: A systematic review and meta-analysis

2026

BACKGROUND: Long-acting injectable pre-exposure prophylaxis (LAI-PrEP) is a highly effective biomedical intervention for the prevention of HIV acquisition. There is a strong interest among communities and policymakers for LAI-PrEP scale-up,...

HIV risk and prevention among cisgender men who have sex with transgender women or transfeminine nonbinary people

2026

No abstract available

Risk factors for HIV-associated neurocognitive impairment and frailty in aging people with HIV in Latin America: A systematic review

2026

No abstract available

HIV Mortality Surveillance in Nigeria, A Systematic Review of Trends, Determinants, and Implications For Public Health Policy

2026

Despite substantial progress in expanding antiretroviral therapy (ART) coverage and scaling up prevention interventions, Human Immunodeficiency Virus (HIV) related mortality remains a significant public health challenge in several high-burden settings,...

The Gap in Integrated Pediatric Care: A Systematic Review of Family-Based Weight Management for Children Living with HIV

2026

BACKGROUND: As children living with HIV (CWH) achieve longer life expectancy, they face an emerging ‘double burden’ of infectious and non-communicable diseases, specifically pediatric overweight and obesity (OW/OB). This risk...

Preferences for long-acting antiretroviral therapy among people with HIV: A systematic review of discrete choice experiments

2026

BACKGROUND: Long-acting antiretroviral therapy (LA-ART) is emerging as a promising strategy to enhance treatment satisfaction and improve the quality of life for people living with HIV (PLWH). A comprehensive understanding...

Effectiveness and safety of darunavir and lopinavir for treating children and adolescents living with HIV: a systematic review

2026

INTRODUCTION: Darunavir and lopinavir solid formulations are recommended protease inhibitors for treating HIV. An evidence review of their effectiveness/efficacy and safety in young populations was needed to inform the 2025...

HIV and cardiovascular diseases: A systematic review and comparative risk assessment study

2026

BACKGROUND: People living with HIV (PLWH) face a significantly elevated risk of cardiovascular diseases (CVDs). This study aims to quantify temporal trends in HIV-attributable CVD burden at global, regional and...

Efficacy and safety of long-acting lenacapavir for HIV treatment and prevention: A systematic review of randomized trials

2026

BACKGROUND: Lenacapavir is a first-in-class, long-acting HIV-1 capsid inhibitor enabling treatment and prevention with reduced reliance on daily oral adherence. Evidence from randomized trials across indications remains fragmented. We systematically...

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