SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Cost-effectiveness of point-of-care versus centralised, laboratory-based nucleic acid testing for diagnosis of HIV in infants: A systematic review of modelling studies

2023

BACKGROUND: Point-of-care (POC) nucleic acid testing for diagnosis of HIV in infants facilitates earlier initiation of antiretroviral therapy (ART) than with centralised (standard-of-care, SOC) testing, but can be more expensive....

Geographic and population distributions of HIV-1 and HIV-2 circulating subtypes: A systematic literature review and meta-analysis (2010–2021)

2023

BACKGROUND: HIV continues to be a major source of morbidity and mortality. Among the main challenges faced by prophylactic HIV vaccine development are the high rates of genetic mutation and...

Safety of longer-term doxycycline use: A systematic review and meta-analysis with implications for bacterial sexually transmitted infection chemoprophylaxis

2023

BACKGROUND: Sexually transmitted infections (STIs) such as syphilis, gonorrhea, and chlamydia have significantly increased over the past decade in the United States. Doxycycline as chemoprophylaxis (i.e., postexposure prophylaxis) offers promise...

HIV incidence among women engaging in sex work in sub-Saharan Africa: A systematic review and meta-analysis

2023

INTRODUCTION: HIV incidence among women in sub-Saharan Africa (SSA) has declined steadily, but it is unknown whether new infections among women who engage in sex work (WESW) have declined at...

Barriers and facilitators for interventions to improve ART adherence in Sub-Saharan African countries: A systematic review and meta-analysis

2023

BACKGROUND: The HIV/AIDS pandemic remains a significant public health issue, with sub-Saharan Africa (SSA) at its epicentre. Although antiretroviral therapy (ART) has been introduced to decrease new infections and deaths,...

Selenium and zinc supplementation in HIV-infected patients

2023

Background: The Human Immunodeficiency Virus (HIV) epidemic is still a public health concern. Micronutrient deficiencies can fasten the progression of this syndrome. Selenium and zinc are essential trace elements, which exert...

Ageing with HIV: Medicine optimisation challenges and support needs for older people living with HIV: A systematic review

2023

Background: Older people living with HIV (PLWH) are at increased risks of co-morbidities and polypharmacy. However, little is known about factors affecting their needs and concerns about medicines. This systematic review...

“What’s sex and gender got to do with it?” A scoping review of sex and gender-based analysis in pharmacoepidemiologic studies of medication adherence

2023

BACKGROUND: Medication taking is a complex multidimensional behaviour that may be impeded by a range of biological and psychosocial factors, including sex and gender. We aimed to synthesize how sex...

Review of electrocardiographic abnormalities among people living with HIV in Sub-Saharan Africa: A systematic review

2023

INTRODUCTION: Electrocardiographic (ECG) abnormalities are increasingly being reported among people living with HIV (PLWH). However, the exact prevalence of ECG abnormalities among PLWH in Sub-Saharan Africa (SSA), a region with...

Mental health and psychosocial interventions integrating sexual and reproductive rights and health, and HIV care and prevention for adolescents and young people (10–24 years) in sub-Saharan Africa: A systematic scoping review

2023

BACKGROUND: Interventions targeting combined sexual and reproductive health, Human Immunodeficiency Virus (HIV) management and mental health care in sub-Saharan Africa (SSA) are few. There is a need to address common...

Association of apolipoprotein E epsilon 4 and cognitive impairment in adults living with human immunodeficiency virus: A meta-analysis

2023

Background: It is controversial whether the apolipoprotein E epsilon 4 allele (APOE ε4) is a risk gene for human immunodeficiency virus (HIV)-related neurocognitive impairment. This meta-analysis aimed to summarize evidence of...

Progress towards triple elimination of mother-to-child transmission of HIV, hepatitis B and syphilis in Pacific Island Countries and Territories: A systematic review

2023

The diverse geographic, demographic, and societal factors in the Pacific Island Countries and Territories (PICTs) have contributed to unique epidemiological patterns of HIV, syphilis, and hepatitis B. Transmission can be...

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