SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Safety considerations in the management of hepatitis C and HIV co-infection

2023

INTRODUCTION: Both HCV and HIV are highly prevalent infections with current estimates of 57 and 38 million people infected worldwide, respectively. Oral antivirals can be curative for HCV and rescue...

Comparison of clinical manifestations in mpox patients living with HIV versus without HIV: A systematic review and meta-analysis

2023

INTRODUCTION: Currently, many cases of mpox patients living with the human immunodeficiency virus (HIV) have been reported. Immunocompromised mpox patients including those living with HIV are noted for an increased...

Effectiveness of vaccination against SARS-CoV-2 and the need for alternative preventative approaches in immunocompromised individuals: A narrative review of systematic reviews

2023

INTRODUCTION: Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including administration of booster doses, continues to be the most effective method for controlling COVID-19-related complications including progression to severe...

Barriers to uptake of PrEP across the continuum among transgender women: A global scoping review

2023

BACKGROUND: Although preexposure prophylaxis (PrEP) has demonstrated high efficacy for HIV prevention, rates of PrEP uptake remain low among the transgender population, especially in transgender women (TGW). We conducted this...

The use of azithromycin and pyrimethamine for treatment of cerebral toxoplasmosis in human immunodeficiency virus-infected patients: A systematic review

2023

PURPOSE: Toxoplasma gondii is a parasite that is widely distributed around the globe and can cause brain inflammation, particularly in immunosuppressed patients such as those diagnosed with human immunodeficiency virus...

Men who have sex with men and risk for transfusion-transmissible infections in blood donors in Western countries: A systematic review update

2023

Background and objectives: This systematic review update summarizes evidence concerning transfusion-transmissible infections (TTIs) in male blood donors reporting sex with another man (MSM) or after easing the MSM deferral period. Materials...

The application of systems thinking to the prevention and control of sexually transmissible infections among adolescents and adults: A scoping review

2023

Systems thinking is a mechanism for making sense of complex systems that challenge linear explanations of cause-and-effect. While the prevention and control of sexually transmissible infections (STIs) has been identified...

HIV stigma reduction interventions among health care providers and students in different countries: A systematic review

2023

BACKGROUND: Health care providers’ stigmatizing attitudes are obstacles to patients’ well-being and quality of life. Dealing with HIV-related stigma and understanding the impact of feasible interventions on reducing stigmatizing attitudes...

A systematic review of implementation research on determinants and strategies of effective HIV interventions for men who have sex with men in the United States

2023

Men who have sex with men (MSM) are disproportionately affected by HIV, accounting for two-thirds of Men who have sex with men (MSM) are disproportionately affected by HIV, accounting for...

Clinical relevance of drug interactions in people living with human immunodeficiency virus on antiretroviral therapy—Update 2022: Systematic review

2023

BACKGROUND: The clinical outcomes of antiretroviral drugs may be modified through drug interactions; thus, it is important to update the drug interactions in people living with HIV (PLHIV). AIM: To...

Non-pharmacological interventions for improving sleep in people living with HIV: A systematic narrative review

2023

BACKGROUND: Sleep disturbances are common in people living with Human Immunodeficiency Virus (HIV) and may lead to poor adherence to antiretroviral therapy and worsen HIV symptom severity. Due to the...

Diagnostic performance of the HCV core Antigen test to identify hepatitis C in HIV-infected patients: A systematic review and meta-analysis

2023

The standard algorithm for diagnosing hepatitis C virus (HCV) infection has two steps, an HCV antibody test for screening and a nucleic acid amplification test (NAAT) for confirmation. However, the...

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