Category Archives: Neurocognitive disorders
Exploring the potential of cognitive intra-individual variability in HIV care and research in adults with HIV: a concept analysis
Cognitive intraindividual variability (IIV) refers to the variability in one’s ability to sustain consistent cognitive performance. This phenomenon is linked to the emergence of cognitive impairment and dementia. The aim...
Exercise as a preventive and therapeutic strategy for non-communicable diseases in people living with HIV: Evidence, mechanisms and clinical implications
OBJECTIVE: To synthesise evidence on exercise for preventing and managing non-communicable diseases (NCDs) among HIV clients, emphasising sub-Saharan Africa. DESIGN: Narrative review. DATA SOURCES: Meta-analyses, randomised trials, cohort studies, mechanistic...
The impact of APOE Iæ4 on cognitive performance in adults with HIV: a systematic review and meta-analysis
OBJECTIVE: With a rapidly aging population living with HIV that may face a double-hit of neuroHIV and Alzheimer’s disease, the objective of this meta-analysis was to evaluate the impact of...
Risk factors for HIV-associated neurocognitive impairment and frailty in aging people with HIV in Latin America: A systematic review
Background As people living with HIV (PWH) in Latin America and the Caribbean (LAC) have longer life expectancy due to improved access to antiretroviral therapy (ART), complications such as HIV-associated...
Associations between neuroimaging measures and cognitive performance in children, adolescents, and youth living with HIV—A systematic review
PURPOSE OF REVIEW: Neurodevelopmental delays and neuroimaging abnormalities continue to be found in children, adolescents, and youth living with HIV despite the administration of effective combination antiretroviral therapy (cART). However,...
Physical activity counseling for people living with HIV: A scoping review
Objective: To explore evidence on physical activity counseling for people living with HIV (PLHIV). Methods: Searches covered earliest records in PubMed (1946), Embase (1947), Web of Science (1900), Scopus (1788), and LILACS...
Possible prevention of neurodevelopmental consequences of vertical HIV transmission in early childhood? A systematic review
BACKGROUND: Children infected with the Human Immunodeficiency Virus (HIV) exhibit the lowest neurodevelopmental scores. Mother-to-child-transmission prevention include perinatally and early antiretroviral therapy (ART) although long-term effects of in utero exposure...
Association between cerebrospinal fluid CXCL10 and neurocognitive disorders in people living with HIV: A meta-analysis
Background C-X-C motif chemokine ligand 10 (CXCL10) is implicated in HIV-associated neuroinflammation, yet its association with HIV-associated neurocognitive disorders (HAND) remains unclear. We conducted a meta-analysis to evaluate cerebrospinal fluid...
Challenges to physical activity participation among older people living with HIV: Scoping review
Older people living with Human Immunodeficiency Virus (OPLWH) have lower physical activity levels than other population groups. Inadequate physical activity participation increases the risks of age-related non-communicable diseases (NCDs). Therefore,...
Divergent structural and functional brain alterations in HIV-infected patients: A multimodal meta-analysis
Neuroimaging studies have identified brain structural and functional alterations in HIV-infected patients; however, the results are inconsistent. This study aimed to characterize the effects of HIV infection on regional gray...
Studies on cognitive performance among older people living with HIV in eastern Europe and central Asia: A scoping review
BACKGROUND: Despite the growth of the population of older people living with HIV (PLWH), data on cognitive disorders among older PLWH, particularly in low- and middle-income countries, are scarce. These...
