Category Archives: Population(s)
The impact of genital ulcers on HIV transmission has been underestimated—A critical review
In the early 1990s, several observational studies determined that genital ulcer disease (GUD), in either the index or the exposed person, facilitates HIV transmission. Several meta-analyses have since presented associated...
Men missing from the HIV care continuum in sub-Saharan Africa: A meta-analysis and meta-synthesis
Introduction: Men are missing along the HIV care continuum. However, the estimated proportions of men in sub-Saharan Africa meeting the UNAIDS 95-95-95 goals vary substantially between studies. We sought to estimate...
Impact of antiretroviral therapy on kidney disease in HIV infected individuals—A qualitative systematic review
Kidney disease is the fourth most common cause of non-AIDS-related mortality in people living with HIV. Combination antiretroviral therapy (cART) remains the cornerstone of treatment. However, little is known about...
Use of HIV recency assays for HIV incidence estimation and other surveillance use cases: Systematic review
BACKGROUND: HIV assays designed to detect recent infection, also known as “recency assays,” are often used to estimate HIV incidence in a specific country, region, or subpopulation, alone or as...
HIV and STI testing preferences for men who have sex with men in high-income countries: A scoping review
Background: Regular testing for HIV and other sexually transmitted infections (STI) is recommended at least annually for sexually active men who have sex with men (MSM) in most high-income countries....
Adherence to pre-exposure prophylaxis in adolescents and young adults: A systematic review and meta-analysis
This meta-analysis synthesized the proportion of adolescents and young adults (AYAs) who are adherent to pre-exposure prophylaxis (PrEP) and factors moderating adherence. A systematic search was conducted of studies published...
Effects of interleukin-10 -1082G/A and -592C/A gene polymorphisms on the risk of human immunodeficiency virus-1 infection: An updated meta-analysis
This paper has aimed to review the available evidence on the association between Interleukin (IL) -10 -1082G/A, -592C/A gene polymorphisms and the risk of human immunodeficiency virus-1(HIV-1) infection. The data...
Impact of supervised aerobic exercise on clinical physiological and mental parameters of people living with HIV: A systematic review and meta-analyses of randomized controlled trials
Background: The benefits derived from supervised aerobic exercise in people living with human immunofeficiency virus- HIV (PLWH) have not yet been clearly identified.Objective: To evaluate the impact of supervised aerobic exercise on...
Discontinuation, suboptimal adherence, and reinitiation of oral HIV pre-exposure prophylaxis: A global systematic review and meta-analysis
Background: Poor adherence to oral HIV pre-exposure prophylaxis (PrEP) diminishes its clinical and public health benefits. This study synthesises evidence regarding discontinuation, adherence, and reinitiation of PrEP among geographically diverse PrEP...
Effects of different integrase strand transfer inhibitors on body weight in patients with HIV/AIDS: A network meta-analysis
Background: Global antiretroviral therapy has entered a new era. Integrase strand transfer inhibitor (INSTI) has become the first choice in acquired immunodeficiency syndrome (AIDS) treatment. Because INSTI has high antiviral efficacy,...
Effectiveness of interventions for prevention of common infections among opioid users: A systematic review of systematic reviews
BACKGROUND: The North American opioid crisis is marked by high opioid-related mortality and morbidity, including opioid use-associated infections (OUAIs). Users of pharmaceutical and non-pharmaceutical opioids are at an increased risk...
Interventions to improve early retention of patients in antiretroviral therapy programmes in sub-Saharan Africa: A systematic review
BACKGROUND: Several interventions to improve long term retention (12 months and above) on treatment have been rigorously evaluated in Sub-Saharan Africa (SSA). However, research on interventions to improve retention of...
