Category Archives: Population(s)

Population pharmacokinetic simulations for dose optimization of tenofovir disoproxil fumarate in HIV-infected patients with moderate-to-severe renal impairment

2024

Tenofovir disoproxil fumarate (TDF) requires dosage adjustments from the standard 300 mg once daily to every 48–96 h for moderate-to-severe renal impairment to avoid excessive exposure. However, this extended interval...

Drug-drug interactions potential with the HIV-1 capsid inhibitor lenacapavir

2024

INTRODUCTION: Lenacapavir is the first HIV-1 capsid inhibitor administered subcutaneously twice yearly. While lenacapavir is currently only indicated as salvage therapy, it has the potential to become a foundation of...

Adverse perinatal outcomes associated with different classes of antiretroviral drugs in pregnant women living with HIV: A systematic review and meta-analysis

2024

OBJECTIVE: Women living with HIV (WLHIV) are at increased risk of adverse perinatal outcomes compared to HIV-negative women, despite antiretroviral therapy (ART). There is evidence that the risk of adverse...

An analysis of approaches to reduction of HIV stigma across the world through educational interventions: A scoping review

2024

OBJECTIVE: To determinate the educational interventions for reducing the stigma caused by HIV worldwide. METHODS: This scoping review study analyzed all papers published from early 2000 to the end of...

HIV prevention interventions for women who use substances

2024

 Key take-home messages

The impact of HIV and parasite single infection and coinfection on telomere length: A systematic review

2024

HIV and parasite infections accelerate biological aging, resulting in immune senescence, apoptosis and cellular damage. Telomere length is considered to be one of the most effective biomarkers of biological aging....

Effectiveness of harm reduction interventions in Chemsex: A systematic review

2024

The phenomenon of chemsex has emerged as an essential public health issue in recent years. This systematic review aimed to investigate currently available harm reduction strategies and to evaluate the...

Overview of hepatitis B vaccine non-response and associated B cell amnesia: A scoping review

2024

BACKGROUND: The advent of the hepatitis B vaccine has achieved tremendous success in eradicating and reducing the burden of hepatitis B infection, which is the main culprit for hepatocellular carcinoma-one...

Prevalence of extrapulmonary tuberculosis among people living with HIV/AIDS in Southeast Asia: A systematic review and meta-analysis

2024

The dual burden of human immunodeficiency virus (HIV) and tuberculosis (TB) impacts people living with HIV (PLHIV) coinfected with TB. Although some primary studies have been reported on the burden...

A systematic review of factors associated with COVID-19 vaccine uptake, hesitancy, and acceptability among adults with HIV: Implications for integrating COVID-19 immunization into HIV care

2024

The COVID-19 virus, once a public health emergency, is now endemic. Immunization remains an important measure for mitigating high levels of disease, morbidity, and mortality related to COVID-19 infection. People...

Maternal inflammatory and microbial drivers of low birthweight in low- and middle-income countries

2024

BACKGROUND: Low birthweight (LBW) is when an infant is born too soon or too small, and it affects one in seven infants in low- and middle-income countries. LBW has a...

Prevalence of Giardia duodenalis among African children: A systematic review and meta-analysis

2024

BACKGROUND: Giardia duodenalis (G. duodenalis) is one of the major causes of diarrhea among children. We performed a systematic review and meta-analysis to assess the prevalence of G. duodenalis and...

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