Category Archives: General HIV+ population
Reviews on HIV+ people where the population is not specified
From CD4-based initiation to treating all HIV-infected adults immediately: An evidence-based meta-analysis
Background: The World Health Organization (WHO) Consolidated antiretroviral therapy (ART) guidelines set the CD4(+) T-cell counts threshold to 500 cells/mm(3) in 2013, and 2015 guidelines recommend treating all HIV-infected adults...
Systematic review and meta-analysis of cannabinoids in palliative medicine
We provide a systematic review and meta-analysis on the efficacy, tolerability, and safety of cannabinoids in palliative medicine. The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, PsycINFO, PubMed, Scopus,...
Pharmacokinetics of efavirenz in patients on antituberculosis treatment in high HIV and tuberculosis burden countries: A systematic review
AIMS: Efavirenz (EFV) and Rifampicin-Isoniazid (RH) are cornerstone drugs in HIV-tuberculosis (TB) co-infection treatment but with complex drug interactions, efficacy and safety challenges. We reviewed recent data on EFV and...
Prevalence of sexually transmitted infections and bacterial vaginosis among women in sub-Saharan Africa: An individual participant data meta-analysis of 18 HIV prevention studies
BACKGROUND: Estimates of sexually transmitted infection (STI) prevalence are essential for efforts to prevent and control STIs. Few large STI prevalence studies exist, especially for low- and middle-income countries (LMICs)....
Challenges with access to healthcare from the perspective of patients living with HIV: A scoping review & framework synthesis
Accessing healthcare can be difficult but the barriers multiply for people living with HIV (PLHIV). To improve access and the health of PLHIV, we must consider their perspectives and use...
A systematic review of non-traumatic spinal cord injuries in Sub-Saharan Africa and a proposed diagnostic algorithm for resource-limited settings
Background: Non-traumatic myelopathy is common in Africa and there are geographic differences in etiology. Clinical management is challenging due to the broad differential diagnosis and the lack of diagnostics. The...
Effectiveness of protease inhibitor/nucleos(t)ide reverse transcriptase inhibitor-based second-line antiretroviral therapy for the treatment of HIV-1 infection in sub-Saharan Africa: Systematic review and meta-analysis
Background: In sub-Saharan Africa, 25.5 million people are living with HIV, representing 70% of the global total. The need for second-line antiretroviral therapy (ART) is projected to increase in the...
A comprehensive review of HIV/STI prevention and sexual and reproductive health services among sex workers in conflict-affected settings: Call for an evidence- and rights-based approach in the humanitarian response
Background: While the conditions in emergency humanitarian and conflict-affected settings often result in significant sex work economies, there is limited information on the social and structural conditions of sex work...
Patient acceptability and feasibility of HIV testing in emergency departments in the UK — A systematic review and meta-analysis
BACKGROUND: NICE 2016 HIV testing guidelines now include the recommendation to offer HIV testing in Emergency Departments, in areas of high prevalence,(1) to everyone who is undergoing blood tests. 23%...
A systematic review of emergency department based HIV testing and linkage to care initiatives in low resource settings
INTRODUCTION: Only 45% of people currently living with HIV infection in sub-Saharan Africa are aware of their HIV status. Unmet testing needs may be addressed by utilizing the Emergency Department...
