Category Archives: Treatment

Association between antiretroviral therapy adherence and employment status: Systematic review and meta-analysis

2015

OBJECTIVE: To assess the association between the employment status of human immunodeficiency virus (HIV)-infected individuals and adherence to antiretroviral therapy (ART). METHODS: We searched the Medline, Embase and Cochrane Central...

Interferon-free therapies for patients with chronic hepatitis C genotype 3 infection: A systematic review

2016

Treatment of hepatitis C virus (HCV) infection with genotype 3 remains a challenge. The HCV elimination rate with direct-acting antivirals (DAAs) is lower than the values reported for other HCV...

Physical impairment in HIV infections and AIDS: Responses to resistance and aerobic training

2014

AIM: The aim of this paper was to examine impairments in muscle strength and aerobic power associated with HIV and AIDS, to define optimal regimes of resistance and aerobic training,...

Patient-reported barriers and facilitators to antiretroviral adherence in sub-Saharan Africa: A systematic review

2017

OBJECTIVE: To identify the range and frequency of patient-reported barriers and facilitators to antiretroviral treatment (ART) adherence in Sub-Saharan Africa (SSA). DESIGN: Studies from 2005-2016 were identified by searching 10...

Patient-reported barriers to adherence to antiretroviral therapy: A systematic review and meta-analysis

2016

BACKGROUND: Maintaining high levels of adherence to antiretroviral therapy (ART) is a challenge across settings and populations. Understanding the relative importance of different barriers to adherence will help inform the...

Challenges in the evaluation of interventions to improve engagement along the HIV care continuum in the United States: A systematic review

2017

In the United States (US), there are high levels of disengagement along the HIV care continuum. We sought to characterize the heterogeneity in research studies and interventions to improve care...

Clostridium difficile: A healthcare-associated infection of unknown significance in adults in sub-Saharan Africa

2016

BACKGROUND: Clostridium difficile infection (CDI) causes a high burden of disease in high-resource healthcare systems, with significant morbidity, mortality, and financial implications. CDI is a healthcare-associated infection for which the...

Conceptualizing care continua: Lessons from HIV, hepatitis C virus, tuberculosis and implications for the development of improved care and prevention continua

2017

BACKGROUND: To examine the application of continuum models to tuberculosis, HIV, and other conditions; to theorize the concept of continua; and to learn lessons that could inform the development of...

A review of single-tablet regimens for the treatment of HIV-1 infection

2017

OBJECTIVE: To review the pharmacokinetics, safety, drug-drug interactions, and advantages and disadvantages of currently available single-tablet regimens (STRs) for HIV-1 infection. DATA SOURCES: A search using PubMed was conducted (up...

A review of management of inflammation in the HIV population

2016

Advancements in antiretroviral therapy have drastically increased the life expectancy for those infected with HIV. Today, a new subgroup of older patients with long-term controlled HIV exists, and its populace...

Life expectancy of HIV-positive people after starting combination antiretroviral therapy: A meta-analysis

2016

OBJECTIVES: Life expectancy is an important indicator informing decision making in policies relating to HIV-infected people. Studies estimating life expectancy after starting combination antiretroviral therapy (cART) have noted differences between...

Barriers and facilitators of interventions for improving antiretroviral therapy adherence: A systematic review of global qualitative evidence

2016

INTRODUCTION: Qualitative research on antiretroviral therapy (ART) adherence interventions can provide a deeper understanding of intervention facilitators and barriers. This systematic review aims to synthesize qualitative evidence of interventions for...

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