Category Archives: Prevention, Engagement and Care Cascade
Social support networks: An underutilized resource for the prevention of HIV and other sexually transmitted diseases among Hispanic/Latino migrants and immigrants
Hispanic/Latino migrants and immigrants are vulnerable to infection by HIV and other sexually transmitted diseases (STDs). Participation in social support networks helps them cope with circumstances in the U.S. Studies...
Incidence and risk factors for prediabetes and diabetes mellitus among HIV-infected adults on antiretroviral therapy: A systematic review and meta-analysis
OBJECTIVE: To summarize evidence on the rates and drivers of progression from normoglycemia to prediabetes and/or diabetes mellitus (hereafter “diabetes”) in antiretroviral treatment (ART)-exposed HIV-infected people. METHODS: We searched EMBASE,...
Pharmacokinetics of efavirenz in patients on antituberculosis treatment in high HIV and tuberculosis burden countries: A systematic review
AIMS: Efavirenz (EFV) and Rifampicin-Isoniazid (RH) are cornerstone drugs in HIV-tuberculosis (TB) co-infection treatment but with complex drug interactions, efficacy and safety challenges. We reviewed recent data on EFV and...
Factors impacting antiretroviral therapy adherence among human immunodeficiency virus-positive adolescents in Sub-Saharan Africa: A systematic review
OBJECTIVES: Eighty-two percent of human immunodeficiency virus (HIV)-positive adolescents live in Sub-Saharan Africa (SSA). Despite the availability of antiretroviral therapy (ART), adherence levels are suboptimal, leading to poor outcomes. This...
Systematic review of the prevalence of psychiatric illness and sleep disturbance as co-morbidities of HIV infection in the UK
Psychiatric illness and sleeping disorders are important co-morbidities of human immunodeficiency virus (HIV) infection, which impact both the individual and antiretroviral therapy (ART) selection. This systematic review aimed to assess...
Efficacy and safety of boosted darunavir-based antiretroviral therapy in HIV-1-positive patients: Results from a meta-analysis of clinical trials
Darunavir/ritonavir (DRV/r) is a second-generation protease inhibitor used in treatment-naive and -experienced HIV-positive adult patients. To evaluate efficacy and safety in these patient settings, we performed a meta-analysis of randomized...
From CD4-based initiation to treating all HIV-infected adults immediately: An evidence-based meta-analysis
Background: The World Health Organization (WHO) Consolidated antiretroviral therapy (ART) guidelines set the CD4(+) T-cell counts threshold to 500 cells/mm(3) in 2013, and 2015 guidelines recommend treating all HIV-infected adults...
Strategies for improving the lives of US women aged 40 and above living with HIV/AIDS: An evidence map
BACKGROUND: While in its early years the HIV epidemic affected primarily the male and the young, nowadays, the population living with HIV/AIDS is approximately 24% women, and its age composition...
HIV-positive women have higher risk of HPV infection, precancerous lesions, and cervical cancer: A systematic review and meta-analysis
OBJECTIVES: HIV-positive women have higher human papillomavirus (HPV) prevalence and cervical cancer (CC) incidence than HIV-negative women, partly due to HIV’s modifying effect on HPV pathogenesis. We synthesized the literature...
Effect of point-of-care diagnostics on maternal outcomes in human immunodeficiency virus-infected women: Systematic review and meta-analysis
Introduction: The World Health Organization advocates for increased accessibility of HIV-related point-of-care (POC) diagnostics in settings that lack laboratory infrastructure. The aim of this study is to assess the impact...
