Category Archives: Biomedical interventions
Effects of Tenofovir disoproxil fumarate on bone quality beyond bone density—A scoping review of the literature
Tenofovir disoproxil fumarate (TDF) is a widely used pharmacological agent for the treatment of human immunodeficiency virus infection. While prolonged exposure to TDF has been associated with a decrease in...
Incidence and risks of HIV infection, medication options, and adverse effects in accidental needle stick injuries: A narrative review
Accidental needle sticks can lead to infections, including HIV. As scientists have learned more about HIV and its replicative physiology, identification of target sites and novel medications have been developed....
The safety and immunogenicity of vaccines administered to pregnant women living with HIV: A systematic review and meta-analysis
Background Human Immunodeficiency Virus (HIV)-exposed uninfected (HEU) infants have a higher burden of infectious diseases related morbidity and mortality compared with HIV-unexposed uninfected (HUU). Immunization of pregnant women living with...
A community guide systematic review: Digital HIV pre-exposure prophylaxis interventions
INTRODUCTION: HIV preexposure prophylaxis (PrEP) is highly effective when taken as prescribed. Digital health adherence interventions have been identified as effective for improving antiretroviral therapy adherence among people with HIV,...
Effectiveness of linkage to care and prevention interventions following HIV self-testing: A global systematic review and meta-analysis
Over 38.4 million people were living with HIV globally in 2021. The HIV continuum includes HIV testing, diagnosis, linkage to combined antiretroviral therapy (cART), and retention in care. An important...
Adherence to option B+ antiretroviral therapy and associated factors in pregnant and breastfeeding women in Sub-Saharan Africa: A systematic review and meta-analysis
Background To assess the adherence to option B + antiretroviral therapy (ART) and associated factors in pregnant and breastfeeding women in Sub-Saharan Africa (SSA). Methods We conducted a comprehensive search from 01st January...
HIV prevention and treatment interventions for Black men who have sex with men in Canada: Scoping systematic review
BACKGROUND: Black men who have sex with men (MSM) experience disproportionately high HIV incidence globally. A comprehensive, intersectional approach (race, gender, and sexuality or sexual behavior) in understanding the experiences...
Prevention of viral hepatitis and HIV infection among people who inject drugs: A systematic review and meta-analysis
This study aimed to explore the current evidence on preventing blood-borne virus infections among people who inject drugs (PWID). We conducted a comprehensive search across three databases (PubMed, Embase, Cochrane...
Influences affecting decision-making regarding use of pre-exposure prophylaxis among black men who have sex with men in the USA: A systematic review and meta-synthesis
AIM: To systematically identify, evaluate, and synthesise qualitative research examining positive and negative influences affecting decision-making behaviour among black men who have sex with men (BMSM) in the USA regarding...
Adverse effects of daily oral pre-exposure prophylaxis in men who have sex with men and transgender women: A systematic review and meta-analysis
The adverse effects of oral pre-exposure prophylaxis (PrEP) using tenofovir disoproxil fumarate are barriers to PrEP initiation and continuation. Although serious effects are rare and predictable, evidence for this assessment...
Pre-exposure prophylaxis adherence among men who have sex with men: A systematic review and meta-analysis
OBJECTIVES: The effectiveness and efficiency of pre-exposure prophylaxis (PrEP) in reducing the transmission of HIV among men who have sex with men (MSM) relies on how widely it is adopted...
