Category Archives: Treatment
Impact of HIV coinfection on tuberculosis treatment outcomes in Ethiopia: A systematic review and meta-analysis
Objectives: Despite the implementation of a short-term direct observation treatment programme, HIV coinfection is one of the main determinants of tuberculosis (TB) treatment success. This meta-analysis was conducted to report the...
Discrepancies between self-reported medication in adherence and indirect measurement adherence among patients undergoing antiretroviral therapy: A systematic review
Background Given the critical importance of medication adherence in HIV/AIDS treatment, this study aims to compare medication adherence measured by self-report (SR) and indirect measurement among antiretroviral therapy (ART) patients,...
Explaining inequity in knowledge, attitude, and services related to HIV/AIDS: A systematic review
BACKGROUND: Equitable service provision and coverage are important responses to end the threat of the HIV/AIDS pandemic. Understanding inequity supports policies and programmes to deliver tailored interventions. There is continuous...
Cancer risk in people living with HIV and solid organ transplant recipients: A systematic review and meta-analysis
Background: Systematic evaluations of cancer risk in people living with HIV or AIDS (PLHIV) and solid organ transplant recipients provide unique insights into the role of the immune system in cancer...
Highly active antiretroviral therapy is necessary but not sufficient. A systematic review and meta-analysis of mortality incidence rates and predictors among HIV-infected adults receiving treatment in Ethiopia, a surrogate study for resource-poor settings
Background Owing to the introduction of highly active antiretroviral therapy (HAART), the trajectory of mortality and morbidity associated with human immunodeficiency virus (HIV) infection has significantly decreased in developed countries....
Implementation strategies to improve HIV care cascade outcomes in low- and middle-income countries: A systematic review from 2014 to 2021
INTRODUCTION: In low- and middle-income countries (LMICs), which are disproportionately affected by the HIV epidemic and manage limited resources, optimized implementation strategies are needed to enhance the efficiency of the...
Incidence and predictors of tuberculosis among HIV-infected children after initiation of antiretroviral therapy in Ethiopia: A systematic review and meta-analysis
BACKGROUND: Globally, Tuberculosis (TB) is the main cause of morbidity and mortality among infectious disease. TB and Human Immune Virus (HIV) are the two deadly pandemics which interconnected each other...
Systematic review and meta-analysis on the effect of depression on ART adherence among women living with HIV
BACKGROUND: Depression is a very common psychiatric disorder in worldwide. Globally, Human Immunodeficiency Virus (HIV) is highly prevalent among women, and are disproportionately affected by depression. Antiretroviral Therapy (ART) adherence...
Prevalence and determinants of under-nutrition among children on ART in Ethiopia: A systematic review and meta-analysis
BACKGROUND: Children living with HIV/AIDS are particularly vulnerable to under-nutrition. Under-nutrition associated with HIV/AIDS infection increases the rate of morbidity and mortality in children. To reaffirm a future objective, there...
Pharmacovigilance in pregnancy studies, exposures and outcomes ascertainment, and findings from low- and middle-income countries: A scoping review
Introduction Pharmacovigilance (PV), or the ongoing safety monitoring after a medication has been licensed, plays a crucial role in pregnancy, as clinical trials often exclude pregnant people. It is important...
Virological outcomes of third-line antiretroviral therapy in a global context: A systematic reviews and meta-analysis
Background: Despite remarkable progress, HIV’s influence on global health remains firm, demanding continued attention. Understanding the effectiveness of third-line antiretroviral therapy in individuals who do not respond to second-line drugs is...
Antenatal depression and its predictors among HIV positive women in Sub-Saharan Africa; a systematic review and meta-analysis
BACKGROUND: Antenatal depression in Human Immunodeficiency Virus (HIV) positive pregnant women can have significant adverse effects on both the mother and newborns, yet it is often overlooked in pregnancy care...