SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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High HIV viral suppression among adults receiving WHO-recommended first-line dolutegravir-based antiretroviral therapy in low- and middle-income countries: A systematic review and meta-analysis of programmatic evidence

2025

Background This systematic review and meta-analysis assessed viral suppression among adults receiving WHO-recommended first-line dolutegravir-based ART in programmatic settings in low- and middle-income countries (LMICs). Methods A systematic search of...

Oral pre-exposure prophylaxis initiation, continuation and adherence among pregnant and postpartum women receiving antenatal and postnatal care: A systematic review

2025

INTRODUCTION: In 2023, one-fourth of new HIV acquisitions in children globally resulted from vertical transmission following incident HIV during pregnancy or breastfeeding. Oral pre-exposure prophylaxis (PrEP) with tenofovir disoproxil and...

Contextual and culturally adapted interventions to improve HIV outcomes: A scoping review

2025

BACKGROUND: Antiretroviral therapy is widely available, yet structural, social, and cultural barriers still limit human immunodeficiency virus prevention and care. Prevention tools such as consistent condom use and pre-exposure prophylaxis...

The reasons of late diagnosis in patients with HIV/AIDS: A meta-synthesis

2025

PURPOSE: To comprehensively integrate qualitative findings on the reasons of late diagnosis in HIV/AIDS patients and to encourage timely clinic consultations for advisory purposes. METHODS: A qualitative systematic review utilizing...

Risk factors and mortality rates for children co-infected with HIV and TB in Ethiopia: A systematic review and meta-analysis

2025

This systematic review and meta-analysis aimed to identify risk factors and mortality rates in HIV and TB co-infected children in Ethiopia. An electronic literature search was conducted using multiple databases,...

Enhancing HIV cognitive abilities and self-management through information technology-assisted interventions: Scoping review

2025

BACKGROUND: HIV/AIDS remains a significant global challenge, and with the rapid advancement of technology, there has been an increasing number of interventions aimed at improving HIV/AIDS cognition and self-management behaviors...

Risk factors associated with human Mpox infection: A systematic review and meta-analysis

2025

BACKGROUND: Mpox emerged as a significant global public health concern during the 2022-2023 outbreak, impacting populations in both endemic and non-endemic countries. This study reviews and synthesises evidence on the...

Associations between depressive symptoms and memory functions in persons with HIV: A systematic review and meta-analysis

2025

Episodic memory impairment can persist in persons with HIV (PWH) despite treatment. Depression is among the most prevalent comorbidities in HIV. Changes to brain regions involved in episodic memory like...

The global prevalence and impact of steatotic liver disease and viral infections: A systematic review and meta-analysis

2025

Background: Steatotic liver disease (SLD) affects ~30% of adults worldwide. The global population is continuously threatened by epidemic and endemic viral diseases. This study aims to thoroughly examine the interaction...

Family influences on antiretroviral therapy adherence in youth with HIV in the United States: A systematic review

2025

HIV poses a significant issue in the United States and understanding how HIV-positive populations adhere to treatments, specifically with antiretroviral therapy (ART), is vital for researchers to find approaches to...

Prevalence of HIV drug resistance among patients experiencing first-line treatment failure in Ethiopia: A systematic review and meta-analysis

2025

Background The emergence of human immunodefiency virus (HIV) drug resistance presents a substantial challenge. Alternatives for effective treatment regimens are limited, and treatment strategies are complicated. Although a number of...

Magnitude and characteristics of unsuppressed HIV viral load in children and adolescents on antiretroviral therapy in sub-Saharan Africa: A systematic review and meta-analysis

2025

Background: HIV/AIDS remains a major health issue in sub-Saharan Africa, especially among children and adolescents, with a substantial proportion of people with HIV having unsuppressed viral loads despite the availability of...

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